Ph.D., National Taiwan University
Address: Room 10, 11F, College of Medicine, NTU.
TEL: (02)23123456 -88319
Drug development for neuroprotection: in vitro and in vivo
Synaptic plasticity, learning and memory
Anti-cancer drug development
Osteoporosis, bone formation and bone resorption
Gnen defect related to parkinsonism, schizophrenia
6] Neuropathic pain
Many degenerative central neuronal diseases (for example: stroke, parkinsonism, Huntington’s disease and Alzheimer’s disease) are not very satisfactorily managed. It is very important to develop neuroprotectants to prevent neuronal death induced by ischemia-reperfusion, free radical, dopamine, b-amyloid peptide etc. We focus on the develop of the neuroprotective agents for the following neurodegenerative diseases, such as stroke, Parkinsonism, Huntington’s disease, glutamate-induced neurotoxicity and Alzheimer’s disease with the specific animal models and the primary cultures. We have also found a few compounds which are able to enhance learning and memory. In addition, we also deveted to the study of neuronal plasticity, mechanism and treatment of neuropathic pain. To address this, electrophysiological, immunohistochemistry and biochemical approaches are used. We also corporate with clinician to study the metabolism of bone and develop new drugs for the treatment of osteoporosis and cancer metastasis to bone. Bone formation and bone resorption are evaluated using both in vitro cell cultures and in vivo animal models. We have technically transferred a protein drug targeting avb3 integrin to pharmaceutical company.
1] Increase of oxidative stress by a novel PINK1 mutation, P209A. Free Radical Biology & Medicine, 2012.[Abstract]
2] A forward loop between glioma and microglia: glioma-derived extracellular matrix-activated microglia secrete IL-18 to enhance the migration of glioma cells. J. Cell Physiol, 227:558-568. 2012 . [Abstract]
3] 15-Deoxy-∆12,14-prostaglandin J2 inhibits TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts. J. Cell Physiol,226: 3242-3250. 2011. [Abstract]
4] Impairment of oxidative stress-induced heme oxygenase-1 expression by the defect of Parkinson-related gene of PINK1. J. Neurochem,117: 643-653. 2011. [Abstract]
5] Glioma: Role of integrin in pathogenesis and therapy. Tumors of the Central Nervous System, Volume 1 Chapter 7,(Book chapter), 2011. [Abstract]
1] Neuroprotection: cortex neuronal culture, animal
models using different compounds for the induction of different
2] Behavioral models for the study of learning and
memory: rotarod, water maze, passive and active avoidance.
3] Brain slice: for the study of neuronal plasticity,
4] Chung’s neuropathic model and formalin-induced
pain: developing drugs for the treatment of pain.
5] Osteoblast and osteoclast cultures: for the study
of bone metabolism and the development of drugs for the treatment of osteoporosis.
6] Induction of osteoporosis by sciatic nerve section or ovarictomy.
1] Set up for patch clamp recordings: including
amplifiers, pClamp software, air table, manipulator, oscilloscope
Biometra RT-PCR instrument
3] Set up for brain slice recordings