MD, National Taiwan University
Ph.D., Stanford University
Address: 1154 Room, 11F, College of Medicine, NTU.
TEL: (02)23123456 -88588
2] Cell migration & cancer metastasis
3] Ca2+ signaling
Interactions among signaling modules in cell migration
Cell migration is important for embryonic development, immune response, tissue regeneration and cancer metastasis. Recent reports have indicated that different signaling modules have to coordinate temporally and spatially for efficient cell migration. However, how these modules are controlled for synchronized activities is still not clear. Our preliminary data suggest that these signaling modules interact closely to each other, for proper cell migration and for maintenance of vascular integrity. This hypothesis will be examined by multi-disciplinary approaches, including the combination of small molecule inhibitors and RNA interference, 2-dementional cell migration assays and 3-dimentional angiogenesis experiments, computational image analysis and quantification. Through these approaches will we better understand cell migration and cell-cell interaction, and further identify molecular targets for novel therapeutics.
Ca2+, diacylglycerol and STIM1 signalling system regulates
directed cell migration. Nature Cell Biology
Dosage of Dyrk1a Shifts Cells
within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter
the Cell Cycle. Molecular Cell 52:87-100,
The proliferation-quiescence decision is controlled by a bifurcation in
CDK2 activity at mitotic exit. Cell
A localized Wnt signal orients asymmetric stem cell division in
vitro. Science 339:1445-8, 2013.
External push and internal pull forces recruit
curvature-sensing N-BAR domain proteins to the plasma membrane.
Nature Cell Biology 14:874-81, 2012.
Ca2+ pulses control local cycles of lamellipodia
retraction and adhesion along the front of migrating cells.
Current Biology 22:837-42, 2012.
Pyogenic liver abscess as endemic disease,
Taiwan. Emerging Infectious Diseases
6] Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells. Current Biology 22:837-42, 2012.
7] Pyogenic liver abscess as endemic disease, Taiwan. Emerging Infectious Diseases 14:1592-600, 2008.
1] Live cell imaging system 活細胞影像系統 (建構中)
2] Ca2+ imaging system 鈣離子影像系統
(Figure: Human umbilical vein endothelial cells migrate toward
the central open space in a wound-healing assay. The nuclei are labeled
with Hoechst. Color lines represent traces of cell migration over 12 hours.)