Lab No. R936
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B.S. 1983, National Taiwan University, Department of Chemistry
M.S. 1985, National Yang-Ming Medical College, Institute of Biochemistry
Ph.D. 1992, University of North Carolina at Chapel Hill, Department of Biochemistry and Biophysics

Research Interests

Telomeres are the physical ends of eukaryotic linear chromosomes. They are important for the maintenance of chromosome integrity. One of the main goals of my research is to understand the structure and function of telomeres. Using budding yeast Saccharomyces cerevisiae as a model organism, the function of a telomere binding protein, Cdc13p, was analyzed. The role of several proteins including yeast Ku protein, Gbp2p, Rlr1p, and Imp4p in mediating telomere length maintenance are also our research interests. Since telomerase activity is implicated as an essential step for tumor formation in human, my laboratory is also interested in identifying agents that inhibit telomerase activity. Moreover, we are also interested in analyzing the genes that are involved in senescence. Among them, we are currently focused on determining the role of the pituitary tumor transforming gene (PTTG1) in senescence.

In addition to telomere-related researches, we are also interested in applying chemical approach to address biological questions. A series of mechanism-based chemical probes for labeling selected protein families including protein tyrosine phosphatases, protein kinases, and serine proteases were designed and synthesized. We are interested in developing these chemical probes as technical platforms for biological analysis.

Professional Experience & Honors
Professor 2012-present, Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
Visiting Scientist 2009-2010, Department of Biochemistry, University of Washington, Seattle, USA (hosted by Dr. Trisha N. Davis).
Professor 2002-2012, Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Adjunct Professor 2003-2005, Department of Chemistry, National Taiwan University, Taipei, Taiwan, ROC.
Adjunct Associate Professor 2000-2002, Department of Chemistry, National Taiwan University, Taipei, Taiwan, ROC.
Associate Professor 1996-2002, Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.
Postdoctoral Fellow 1995-1996, Princeton University, Department of Molecular Biology, NJ, USA.
Postdoctoral Fellow 1992-1995, Fred Hutchinson Cancer Research Center, Basic Sciences, WA, USA.

Selected Recent Publication

Yu, T.-Y., Kao, Yu-wen, and Lin, J.-J.*: Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase. Proc. Natl. Acad. Sci. USA, 111: 3377-3382, 2014.

Chu, C.-Y., Chang, C.-P., Chou, Y.-T., Handoko, Hu,Y.-L., Lo,L.-C.*, and Lin, J.-J.*: Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein. J. Med. Chem., 56: 2841-2849, 2013.

Chen, C.-L., Chang, D.-M., Chen, T.-C., Lee, C.-C., Hsieh, H.-H., Huang, F.-C., Huang, K.-F., Guh, J.-H., Lin, J.-J.*, and Huang, H.-S.*: Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology. Eur. J. Med. Chem., 60: 29-41, 2013. (co-corresponding author)

Huang, F.-C., Chang, C.-C., Wang, J.-M., Chang, T.-C., and Lin, J.-J.*: Induction of senescence in cancer cells by a G-quadruplex stabilizer BMVC4 is independent of its telomerase inhibitory activity. Brit. J. Pharm., 167: 393-406, 2012.

Yu, T.-Y., Wang, C.-Y., and Lin, J.-J.*: Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p. PLoS One, 7: e33498, 2012. 

Lee, C.-C., Hsu, J.-J., Huang, F.-C., Shih, K.-N., Huang, K.-F., Chen, C.-L., Chen, T.-C., Chen, R.-H., Lin, J.-J.*, and Huang, H.-S.*: Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones. Eur. J. Med. Chem., 50:102-112, 2012. (co-corresponding author)

Hsu, Y.-H., Liao, L.-J., Yu, C.-H., Chiang, C.-P., Jhan, J.-R., Chang, L.-C., Chen, Y.-J., Lou, P.-J.*, Lin, J.-J.*: Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. J. Biol. Chem., 285:22630-22638, 2010.

Huang, Y.-Y., Kuo, C.-C., Chu, C.-Y., Huang, Y.-H., Hu, Y.-L. Lin, J.-J.*, and Lo, L.-C.*: Development of activity-based probes with tunable specificity for protein tyrosine phosphatase subfamilies. Tetrahedron, 66:4521-4529, 2010. (co-corresponding author)

Wu, T.-J., Chiang, Y.-H., Lin, Y.-C., Tsai, C.-R., Yu, T.-Y., Sung, M.-T., Wu Lee, Y.-H., and Lin, J.-J.*: Sequential loading of Saccharomyces cerevisiae Ku and Cdc13p to telomeres. J. Biol. Chem., 284: 12801-12808, 2009.

Huang, F.-C., Chang, C.-C., Lou, P.-J. Kuo, I.-C., Chien, C.-W., Chen, C.-T. Shieh, F.-Y., Chang, T.-C.*, and Lin, J.-J.*: G-quadruplex stabilizer BMVC induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mole. Cancer Res. 6: 955-964, 2008.

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