蕭裕源 教授

Yuh-Yuan Shiau, Professor

國立台灣大學 牙醫學士 民國五十六年

美國密西根大學 咬合學碩士 民國六十八年

DDS National Taiwan University 1967

MS University of Michigan 1979

主要研究領域

咀嚼系統生理學:

就人體咀嚼器官如牙齒、牙周、顎骨、頭頸部肌群及神經系統在咀嚼、吞嚥、發音等功能執行上所扮演的角色做慎密之觀察與分析,所使用之儀器為肌電圖、咬力測試器、光電及磁極顎運動追蹤器、以及顎運動紀錄與分析系統。為了觀察咬合面型態對咀嚼功能之影響,使用電腦咬合型態分析器;為測知咀嚼肌之肌量,也使用磁共振攝影及超音波系統;為測知咬力及咀嚼功能、咀嚼效率,則發展已知硬度之人工食物。人工食物之硬度,可食性及水溶性之要求,需持續發展。

顎關節及咀嚼肌疼痛及功能失常之研究:

由於顎關節病變,或非病理性型態及位置變化引起的顎功能失常,或因肌緊張、肌疲乏及肌創傷等理由而引起肌痛或肌功能失常。在肇因、發生率、疼痛表現、顎功能變化情形及診斷、治療等方面曾有廣泛的探討。現階段則較注重診斷方法及功能障礙程度之評估,對於各種臨床檢查及儀器檢查、影像檢查等方法及其有效性特別重視。

臨床補綴學研究:

除了探討咬力、咬合面型態及顎關節與肌功能失常對裝戴補綴物後咀嚼功能影響之研究外,在人工牙根補綴設計、磁性附聯體之使用及設計方面亦為臨床研究之重點。在磁性附聯體方面已與日本愛知製鋼合作,開發不同形體、大小之新磁體,提供臨床使用,將是我們在牙科補綴方面重要的研究方向。

 

Main Research Interests

Physiology of the masticatory system:

The human masticatory system includes teeth, periodontal structures, jaw and alveolar bones, musculature of head and neck, and the neural complex. The physiology of this system includes chewing, swallowing and phonation. The roles of this system on the physiologic functions are observed with the use of electromyography, bite force transducers, jaw motion tracking devices (optoelectric and magnetoelectric devices) for a better understanding of the masticatory function. Computer CAD/CAM system is used to observe the three dimensional occlusal form. For the observation of muscle size and orientation. MRI system and self developed reconstruction and measurement softwares are also applied. Ultrasound detection of the muscle size is another alternative. For the observation of biting force and chewing efficiency, standardized testfoods of known hardness were developed and applied. Further improvement on the hardness, edibility and water solubility will be emphasized in future studies.

Temporomandibular joint and muscle pain dysfunction:

Some temporomandibular joint diseases of morphological and positional changes may cause pain and dysfunction of the masticatory system. Some emotional tension, frustration and stress may also cause pain and dysfunction of the muscles. We have been working with the prevalence, etiology, symptomatology and functional analysis of the disorders of the system. Recent studies are related more on the diagnostic modality and the evaluation of functional disturbances. Clinical and laboratory examinations including image analysis and its validity and sensitivity are emphasized.

Clinical studies on prosthetic dentistry:

In addition to the studies on the post-prosthetic jaw movement and muscle function related bite force and dental occlusion, dental implant and magnetic attachment are also studied. The design and the use of the magnetic attachment on pulpless tooth and implant abutment are undergoing with the collaboration of Aichi Steel Co. in Japan. New magnet attachments will be developed and manufactured for dental clinical use. The design of magnet attachment on abutment of dental implant will be the main target of magnet studies in our department.

 

五年內研究著作

A.  期刊論文

 

1.       Shiau, Yuh-Yuan; Peng, Chun-Chi; Hsu, Chein-Wen : Evaluation of biting performance with standardized testfoods. Journal of Oral Rehabilitation 26:447-452, 1999.(SCI)

2.       Shiau, Yuh-Yuan : The Goals and Guidelines for the Teaching of Occlusion. Journal of Medical Education 3(1): 11-18, 1999.

3.       Wang, Juo-Song; Lin, Li-Deh; Hong, Chi-Yuan; Lin, Chun-Pin; Lee, Wan-Hsuan; Shiau, Yuh-Yuan: The differences between single and multiple diagnostic group in the classification of temporomandibular disorders. Chin Dent J 18:207-216, 1999.

4.       Tsai, Yau-Wei; Chia, Jean-Shan; Shiau, Yuh-Yuan; Chou, Hsiu-Chuan; Liaw, Yen- Chywan; Lou, Kuo-Long: Three-dimensional modelling of the catalytic domain of Streptococcus mutans glucosyltransferase GtfB. FEMS letters 188:75-79, 2000 ---(SCI)

5.       Hsu, Chien-Wen; Shiau, Yuh-Yuan; Chen, Chung-Ming; Chen, Kun-Chee; Liu, Hon-Man: Measurement of the Size and Orientation of Human Masseter and Medial Pterygoid Muscles. Proc Natl Sci Counc ROC(B) 25(1):45-49, 2001.(correspondence)

6.       Mou, Shu-Hui; Chai, Tsongi; Shiau, Yuh-Yuan; Wang, Juo-Song: Fabrication of conventional complete dentures for a left segmental mandibulectomy patient. A clinical report. J Prosthet Dent 86(6):582-585, 2001. (SCI)correspondence

7.       Lou, Kuo-Long; Chou, Hsiu-Chuan; Tsai, Yau-Wei; Shiau, Yu-Shuan; Huang, Po-Tsang; Chen, Ting-Yu; Shiau, Yuh-Yuan; French, Robert J.: Involvement of a novel C-terminal kinase domain of Kir6.2 in the K-ATP channel rundown reactivation. J Mol Model 7:20-25, 2001. (SCI)correspondence

8. Shiau, Yuh-Yuan; Chang, Chin-Shun; Chiu, Ching-Hwa; Chi, Lin-Yang; Lu, Hsien-Kun: Manpower and education of dentists in Taiwan. J Med Education 5:3-12, 2001.

9. Mou, Shu-Hui; Chai, Tsong-yi; Wang, Juo-Song; Shiau, Yuh-Yuan: Influence of different convergence angles and tooth preparation heights on the internal adaptation of Cerec crowns. Journal of Prosthetic Dentistry 87(3):248-255, 2002.SCI)(correspondence

10.   Huang, P.T.; Chen, T.Y.; Tseng, L.J.; Lou, K.L.; Liou, H.H.; Lin, T.B.; Spatz, H.C. & Shiau, Y.Y.: Structural influence of Hanatoxin Binding on the Carboxyl Terminus of S3 segment in Voltage-Gated K+-channel Kv2.1. Receptors and Channels 8:79-85, 2002. (SCI) correspondence

11.   Sun, Lei-Ming; Tsung, Han-Ming; Shiau, Yuh-Yuan; Chen, Shyh-Jye; Tzeng, Ching-Shiow; Tang, Yueh-Bih : Computer-generated simulation template for Fronto-Naso-orbital reconstruction. Formosan J Surg 35: 28-33, 2002.

12.   Shiau, Yuh-Yuan; Peng Chun-Chi; Wen, Shih-Cheng; Lin, Li-Deh; Wang, Juo-Song; Lou, Kuo-Long : The effects of masseter muscle pain on biting performance. Journal of Oral Rehabilitation , 2002 (SCI)correspondence

13.   Lou, Kuo-Long; Huang, Po-Tsang; Shiau, Yu-Shuan; Shiau, Yuh-Yuan: Molecular seterminants of the hanatoxin binding in voltage-gated K+-channel drk1. Journal of Molecular Recognition 15:175-179, 2002. (SCI)correspondence

14.   Shiau, Yu-Shuan; Lin, Tze-Bin; Liou, Horng-Huey; Huang, Po-Tsarng; Lou, Kuo-Long; Shiau, Yuh-Yuan : Molecular simulation reveals structural determinants of the hanatoxin binding in Kv2.1 channels. Journal of Molecular Modeling 2002 8: 253-257 (SCI)correspondence

15.   Shiau, Y.Y. 2002: The application of root keeper system for handicapped patients. The Journal of the Japanese Society of Magnetic Application in Dentistry 11:1-9

16.   Shiau, Y.Y.; Wang, R.S.; Lin, L.D.; and Lou, K.L. 2003: The masseter muscle pain in biting force performance. Journal of Oral Rehab 87:248-255 (SCI)

17. Chia, J.S.; Shiau, Y.S.; Shiau Y.Y.; Huang, P.T. and Lou, K.L. 2003: Structural analysis of the functional influence of surface peptide Gtf-Pl on enzyme activity in S. mutans glucosyltransferase GtfC. Journal of Molecular Modeling (in press)

18. Lou, K.L.; Shiau Y.S.; Huang P.T.; French R.J.; Liaw Y.C.; Shiau, Y.Y. and Liou H.H. 2003: A possible molecular mechanism of Hanatoxin binding-modified gating in voltage-gated potassium channels. Journal of Molecular Recognition (SCI) (correspondence)

19. Yu-Shuan Shiau, Po-Tsang Huang, Horng-Huei Liou, Yen-Chywan Liax, Yuh-Yuan Shiau, and Kuo-Long Lou : Structural Basis of Binding and Inhibition of Novel Tarantula Toxins in Mammalian Voltage-Dependent Potassium Channels.Chem Res Toxicol 16:1217-1225, 2003(SCI).

 

B.研討會論文

國內研討會:

1.       Shiau, Yuh-Yuan (1999) : Plenary Lecture. A review and outlook of modern dentistry. 92nd General Session, Formosa Medical Association. Nov 11, 1999. Taipei.

2.       Shiau, Yuh-Yuan (2001) : 23rd Asia Pacific Dental Congress, Taipei, Taiwan.

國外研討會:

1.       Shiau, Yuh-Yuan; Peng, CC; Hsu, CW: 1998, June. Measurement of masseter muscle size and bite force. 76th Genernal Session of the International Association for Dental Research, Nice, France.

2.       Peng, CC; Hsu, CW; Shiau, Yuh-Yuan: 1998, June. The size and orientation of the masseter and medial pterygoid muscles. 76th Genernal Session of the International Association for Dental Research, Nice, France.

3.       Shiau, Yuh-Yuan, Peng, CC; Hsu, CW: 1999, March. The effect of jaw biomechanics and muscle volume on biting performance. 77th Genernal Session of the International Association for Dental Research, Vancouver, Canada.

4.       Peng, C.C.; Lu, W.C.; Lin, F.H.; Chai, T.I. and Shiau, Yuh-Yuan: 1999, March. The Flexural Strength of Targis-Vectris System with/without Targis Base. 77th General Session of the International Association for Dental Research, Vancouver, Canada.

5.       Shiau, Yuh-Yuan: 1999, May. The use of the magnetic attachment in Taiwan. 1st. Biennial meeting, Asian Academy of Prosthodontics, Seoul, Korea.

6.       Wen, S.C.; Peng, C.C. and Shiau, Yuh-Yuan: 1999, May. Evaluation of biting ability with known hardness testfood. 1st. Biennial meeting, Asian Academy of Prosthodontics, Seoul, Korea.

7.       Wen, S.C.; Peng, C.C. and Shiau, Yuh-Yuan: 1999, September. Biting force evaluation for myofascial pain patients. IADR/ Malaysia

8.       Shiau, Yuh-Yuan: 2000, March. Magnetic dentistry research in Asian region. 4th International Symposium on Magnetic Dentistry, Tokyo, Japan.

9.       Shiau, Yuh-Yuan; Peng Chun-Chi; Wen, Shih-Cheng; Lin, Li-Deh; Wang Juo-Son: 2000, April. The effects of masseter muscle pain on biting performance. 78th General Session & Exhibition of the International Association for Dental Research, Washinton, DC, USA.

10.   Shiau, Yuh-Yuan: 2001, May. Chair-side installation magnetic system. 5th International Symposium on Magnetic Dentistry, Hong Kong.

11.   Y.Y. Shiau, C.W. Kao, C.M. Wang: 2001, June. Observation on chewing efficiency of fixed prosthodontics. 79th General Session & Exhibition of the International Association for Dental Research, Chiba, Japan.

12.   S.H. Mou, T.U. Chai, J.S. Wang, Y.Y. Shiau: 2001, June. Cerec camera system and internal adaptation of cerec crowns. 79th General Session & Exhibition of the International Association for Dental Research, Chiba, Japan.

13.   Y.Y. Shiau, C.W. Kao, C.M. Wang: 2001, June. Masseter muscle activity and chewing efficiency. 79th Genernal Session & Exhibition of the International Association for Dental Research, Chiba, Japan.

14. Y.W. Tsai, K.L. Lou, J.S. Chia, H.C. Chou, Y.C. Liaw, Y.Y. Shiau: Comparison between GTF 3-D models provides possibility for vaccine development 2001, June. 79th General Session & Exhibition of the International Association for Dental Research, Chiba, Japan.

15. K.N. Ho, C.C. Chang, H.M. Hung, Y.Y. Shiau, C.T. Lin, S.Y. Lee: 2002,March. Vibration assessment of the stability of Root Keeper. 80th General Session IADR, San Diego, California, USA.

16. H.J. Chen, C.M. Wang, K.L. Lou, Y.Y. Shiau: 2002,March. Evaluation of soft food chewing efficiency. 80th General Session IADR, San Diego, California, USA.

17. Y.Y. Shiau, H.J. Chen, C.M. Wang, K.L. Lou: 2002,March. The effect of occlusal contact area on soft food chewing ability. 80th General Session IADR, San Diego, California, USA.

18. T.Oui, C. Peng, L.E. Lin, Y.Y. Shiau: 2002,March. Behaviour of human masticatory mucosa under loads. 80th General Session IADR, San Diego, California, USA.

19. P.T. Hung, Y.Y. Shiau, K.L. Lou,: 2002,Sep. Molecular mechanism of Hanatoxin binding-modified gating in voltage-gated K+-Channels revealed by docking simulation. 17th IADR/SEA Annual Meeting, Hong Kong.

20. Y.J. Ali, M.Y. Wong, K.L. Lou, Y.Y. Shiau, J.H.S. Pang: 2002,Sep. Bactericides forsythus Lipopolysaccharide induce adhesion molecules expression in endothelial cells. 17th IADR/SEA Annual Meeting, Hong Kong.

29. Shiau, Yuh-Yuan (2002) : Plenary lecture: The use of magnetic attachments for denture prosthesis. 6th International Symposium on Magnetic Dentistry, Yokohama, Japan

 

C. 專書及專書論文

1.       蕭裕源,「關節內部紊亂症者之MRI所見」:1997 (章節)

The MRI Findings in Internal Derangement of TMJ

The KMC Dental Journal7(2)39-48

2.       蕭裕源等編著,「顳顎關節障礙症之咬合板治療」:1997,日毅公司出版。(教科書)

3.       蕭裕源編著,「醫學與藝術」:1998,金名圖書公司出版,台大醫學院醫學人文叢書。

4.      蕭裕源著,「新型磁性附連體-根板系統的使用」:2001,日毅公司出版。