CHANG, Bei-En    Ph.D.

 

Department of Zoology, National Taiwan University, BS

Institute of Fisheries Science, National Taiwan University, MS

Institute of Genetics and Molecular and Cellular Biology (IGBMC), Louis Pasteur University, France, Ph.D.

 

 

Assistant Professor

Graduate Institute of Oral Biology, R314

School of Dentistry

College of Medicine

National Taiwan University

Phone: 23123456-66584

E-mail: beien@ntu.edu.tw

 

 

Lu, I-N., Chiang, B-L., Lou, K-L., Huang, P-T., Yao, C-C J., Wang, J-S., Lin, L-D., Jeng, J-H., Chang, B.-E.* (2012). Cloning, expression and characterization of CCL21 and CCL25 chemokines in zebrafish. Developmental and Comparative Immunology 38: 203-214. (NSC96-3111-B-002-003).

Chang, M.-C., Chan, C.-P., Wang, W.-T., Chang, B.-E., Lee, J.-J., Tseng, S.-K. Yeung, S.-Y., Hahn, L.-J., Jeng, J.-H. (2012).Toxicity of areca nut ingredients: activation of CHK1/CHK2. induction of cell cycle arrest, and regulation of MMP-9 and TIMPs production in SAS epithelial cells. Head & Neck (in press)

Chang, M.-C., Chang, H.-H., Chan, C.-P., Chou, H.-Y., Chang, B.-E., Yeung, S.-Y., Wang, T.-M., Jeng, J.-H. (2012). Antiplatelet effect of phloroglucinol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. Toxicology and Applied Pharmacology 263: 287–295.

Huang, C.-T., Lai, E. H.-H., Chang, H.-H., Chang, B.-E., Chen, Y.-H., Wang, Y.-P., Chen, Y.-J., Chang, J. Z.-C., Yao, C.-C. J. (2012). Damage to the root after tooth movement towards a temporary anchorage device: An animal pilot study. Journal of Dental Sciences 7: 171-178.

Weng, W.-C., Lee, W.-T., Hsu, W.-M., Chang, B.-E., Lee, H. (2011). Role of glucose-regulated protein 78 in embryonic development and neurological disorders. J Formos Med Assoc. 110 (7): 428-37.

Chang, H.-H., Wu, C.-B., Chen, Y.-J., Weng, C.-Y., Wong, W.-P., Chang, B.-E., Chen, M.-H., Yao, C.-C.J. (2008). MMP-3 response to compressive forces in vitro and in vivo. Journal of Dental Research 87(7):692-696.

Hou, H.-H, Kuo, M. Y.-P., Luo, Y.-W. and Chang B.-E.* (2006). Recapitulation of human bB1-crystallin promoter activity in transgenic zebrafish. Developmental Dynamics 235, 435-443. (NSC91-2320-B-002-183; NSC92-2320-B-002-196).

Chang, B.-E., Liao, M.-H., Kuo, M. Y.-P. and Chen, C.-H. (2004). Developmental toxicity of arecoline, the major alkaloid in betel nuts, in zebrafish embryos. Birth Defects Res. (A) 70, 28-36. (NSC90-2320-B-002-146).

Chen, J.-Y., Chang, B.-E., Chen, Y.-H., Lin, C. J.-F., Wu J.-L. and Kuo, C.-M.(2001). Molecular cloning, developmental expression, and hormonal regulation of zebrafish (Danio rerio) b crystallin B1, a member of the superfamily of b crystallin proteins. Biochem. Biophys. Res. Commun. 285, 105–110. (NSC90-2320-B-002-146).

Chang, B.-E., Hsieh S.-L. and Kuo C.-M. (2001). Molecular cloning of full length cDNA encoding delta-9-desaturase through PCR strategies and its genomic organization and expression in grass carp (Ctenopharyngodon idella). Mol. Reprod. Dev. 58, 245-254. (NSC89-2311-B-002-024-B28).

Chang, B.-E., Lin, C.-Y., and Kuo, C.-M. (1999) Molecular cloning of a cold-shock domain protein, zfY1, in zebrafish embryo. Biochim. Biophys. Acta, 1433, 343-349. (NSC87-2311-B-002-026-B28).

Muller, F., Chang, B.-E., Albert, S., Fischer, N., Tora, L. and Strahle U. (1999) Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notchord. Development, 126, 2103-2116.

Chang, B.-E., Blader, P., Fisher, N., Ingham, P. W. and Strahle,U. (1997) Axial (HNF3β) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. EMBO J., 16, 3955-3964.

 

Conference Abstracts:

Huo H.-H. and Chang, B.-E. (2003). Analysis of the crystallin-b B1 promoter in transgenic zebrafish. The Eighteenth Joint Annual Conference of Biomedical Sciences, Taipei, p103.

Chang, B.-E., Hsieh S.-L. and Kuo C.-M. (2000). Molecular cloning of full length cDNA encoding delta-9-desaturase through PCR strategies and its expression and genomic organization in grass carp (Ctenopharyngodon idella). Fourth Congress of the Asia and Oceania Society for Comparative Endocrinology, Taipei, p36.

Chang, B.-E., Lin, C.-Y. and Kuo C.-M. (1999). A cold-shock domain protein in zebrafish, Danio rerio. Annual meeting of the Fisheries Society of Taiwan, Kaohsiung, p151.

Chang, B.-E., Hsieh S.-L. and Kuo C.-M. (1999). Molecular cloning of full length cDNA encoding delta-9-desaturase through PCR strategies in grass carp (Ctenopharyngodon idella). Annual meeting of the Fisheries Society of Taiwan, Kaohsiung, p150.

Muller, F., Chang, B.-E., Tora, L., Strahle, U., (1998). Identification of notochord and floor plate-specific enhancers of the sonic hedgehog gene using an in vivo enhancer screening strategy. Symposium on zebrafish development and genetics, p131.

 

 

Research Fields

Craniofacial development

Tooth development

Bone development

 

研究方向

本實驗室主要以斑馬魚及小鼠兩種模式動物為材料,以基因轉殖的方法來探討參與口腔顱顏發育過程中之基因的調控機制及其功能。研究的重點在於眼睛、牙齒及骨骼發育相關基因之啟動子分析,以及利用這些啟動子表現特殊訊息傳遞分子,來干擾正常發育,從而進行這些分子之功能性分析。

Current Research Projects

Analysis of β-Crystallin gene in zebrafish

Craniofacial development

Tooth development

Bone development