江俊斌 教授

Chun-Pin Chiang, Professor

國立台灣大學 牙醫學士 民國六十六年

美國哈佛大學 醫學科學博士 民國七十八年

B.D.S. Dentistry, National Taiwan University, 1977

D.M.Sc. Oral Pathology, Harvard School of Dental Medicine, 1989

 主要研究領域

? 口腔病變之免疫組織化學研究

本研究主要利用單株或多株抗體及免疫組織化學染色法探討致癌基因、抑癌基因、生長因子,生長因子受器,細胞角質於口腔癌前病變(口腔白斑症、上皮變異、疣狀增生、口腔黏膜下纖維化症)、口腔癌(鱗狀細胞癌、疣狀癌)、唾液腺腫瘤(黏液表皮樣癌、腺樣囊狀癌、多形性腺瘤),齒源性囊腫(齒源性角化囊腫,含齒囊腫、根尖牙周囊腫)和齒源性腫瘤(造釉細胞瘤、腺瘤樣齒源性瘤)之表現,進一步探討這些特殊蛋白質表現和口腔習性(嚼檳榔、吸菸、喝酒),臨床參數(患者性別、年齡、腫瘤部位、腫瘤大小、淋巴結轉移、臨床分期)及組織病理學參數(組織學型態、沿血管壁侵犯、沿神經侵犯、腫瘤局部壞死、細胞分化不良)之相關性。此研究對口腔癌前病變之惡性潛能和口腔病變之致病機轉的了解,將有很大的助益。

?口腔癌前和癌病變之光動力診斷與治療

近年來我們發展自體螢光光譜和染料螢光光譜 (5-ALA導引之protoporphyrine IX (PpIX) 螢光光譜) 來協助口腔癌前和癌病變之診斷,我們的研究發現,以330 nm的激發光量測時,於380 nm處之反射螢光光譜強度,口腔黏膜下纖維化症 (OSF) 病變口腔黏膜組織 >正常口腔黏膜組織 >口腔癌前病變 >口腔癌,而於460 nm處之反射螢光光譜強度,則口腔癌 >口腔癌前病變 >正常口腔黏膜組織 > OSF病變口腔黏膜組織。另外利用ALA 導引之PpIX螢光光譜之研究發現,利用410 nm的激發光量測時,於630 nm處之反射螢光光譜強度口腔癌 >口腔癌前病變 >正常口腔黏膜組織 >OSF病變口腔黏膜組織,因此利用此自體螢光光譜和染料螢光光譜之特性將可協助診斷口腔癌前和癌病變,及於大範圍口腔白斑或紅斑性病變中決定適當的切片位置。另外20% ALA也可以用來作口腔癌前病變和口腔癌之光動力治療,我們初步的研究發現其對疣狀癌和疣狀增生的治療效果不錯。


Main Research Interests

? Immunohistochemistry for Oral Lesions

This study used monoclonal and polyclonal antibodies and immunohistochemical method to assess the expression of onco-genes, tumor suppressor genes, growth factors, growth factor receptors and cytokeratins in oral premalignant lesions (oral leukoplakia, epithelial dysplasia, verrucous hyperplasia, oral submucous fibrosis), oral cancers (squamous cell carcinoma, verrucous carcinoma), salivary gland tumors (mucoepidermoid carcinoma, adenoid cystic carcinoma, pleomorphic adenoma), odontogenic cysts (odontogenic keratocyst, dentigerous cyst, apical periodontal cyst), and odontogenic tumors (amelob-lastoma, adenomatoid odontogenic tumor). The expression of these particular proteins was further correlated with oral habits (betel nut chewinq, cigarette smoking, alcohol drinking), clinical parameters (patient's sex, age, tumor location, tumor size, lymph node metastasis, clinical staging) and histopathological para-meters (histological types, perivascular invasion, perineural invasion, focal tumor necrosis, cellular anaplasia) by statistical analysis. This study will help us to understand the malignant potential of oral premalignant lesions and the mechanisms of the development of oral lesions.

? Photodynamic Diagnosis and Treatment of Oral Precancers and Oral cancers

Recently, we develop autofluorescence and ALA-induced protoporphyrine IX (Pp IX) fluorescence spectroscopy to diagnose oral precancers (OPC) and oral cancers (OC). By autofluorescence spectroscopy at 330-nm excitation, the fluorescence intensity of 380-nm emission peak for oral submucous fibrosis (OSF) lesional oral mucosa is greater than those for normal oral mucosa (NOM), OPC and OC in a descending order. On the contrary, the fluorescence intensity of 460-nm emission peak for OC is greater than those for OPC, NOM, and OSF in a descending order. Furthermore, by ALA-induced Pp IX fluorescence spectroscopy at 410-nm excitation, the fluorescence intensity of 630-nm emission peak for OC is greater than those for OPC, NOM, and OSF in a descending order. Therefore, autofluorescence and ALA-induced protoporphyrine IX fluorescence spectroscopy can be used to diagnose OPC, OC, and OSF. They can also used to determine the appropriate sites for biopsy in a large leukoplakia or erthroplakia lesion. In addition the photodynamic therapy (PDT) with 20% ALA is also used to treat OPC and OC. The preliminary results indicate that PDT with 20% ALA is very effective for treating verrucous hyperplasia and verrucous carcinoma.

 

五年內研究著作

A.     期刊論文

 

1.        Sun A, Chang JG, Chu CT, Liu BY, Yuan JH, Chiang CP. 1998. Preliminary evidence for an association of Epstein-Barr virus with pre-ulcerative oral lesions in patients with recurrent aphthous ulcers or Behcet's disease. J Oral Pathol Med 27:168-175. (SCI)  (corresponding author)

2.        Wang KY, Chang FHF, Chiang CP, Chen KC, Kuo MYP. 1998. Temporal and spatial expression of erbB4 in ectodermal and mesenchymal cells during primary palatogenesis in noncleft and cleft strains of mice. J Oral Pathol Med 27:141-146. (SCI)

3.        Kuo MYP, Cheng SJ, Chen HM, Kok SH, Hahn LJ, Chiang CP. 1998.  Expression of CD44s, CD44v5, CD44v6 and CD44v7-8 in betel quid chewing-associated oral premalignant lesions and squamous cell carcinomas in Taiwan. J Oral Pathol Med 27:428-433. (SCI)  (corresponding author)

4.        Chiang CP, Chueh LH, Lin SK, Chen MY. 1998. Oral manifestations in human immunodeficiency virus-infected patients in Taiwan. J Formos Med Assoc 97:600-605. (SCI)

5.        Chen CT, Chiang HK, Chow SN, Wang CY, Lee YS, Tsai JC, Chiang CP. 1998. Autofluorescence in normal and malignant human oral tissues and in DMBA-induced hamster buccal pouch carcinogenesis. J Oral Pathol Med 27:470-474. (SCI)  (corresponding author)

6.        Chiang CP, Kao CY, Liu BY, Wang JT, Lin SK, Kuo MYP. 1998. Reduction of Langerhans cell density in oral epithelium of patients with oral submucous fibrosis. Chin Dent J 17:137-147.

7.        Wang CY, Chen CT, Chiang CP, Young ST, Chow SN, Chiang HK. 1998. Partial least-squares discriminant analysis on autofluorescence spectra of oral carcinogenesis. Appl Spectrosc 52:1190-1196. (SCI)

8.        Wang CY, Chen CT, Chiang CP, Young ST, Chow SN, Chiang HK. 1999. A probability-based multivariate statistical algorithm for autofluorescence spectroscopic identification of oral carcinogenesis. Photochem Photobiol 69:471-477. (SCI)

9.        Wang CY, Chiang HK, Chen CT, Chiang CP, Kuo YS, Chow SN. 1999. Diagnosis of oral cancer by light-induced autofluorescence spectroscopy using double excitation wavelengths. Oral Oncol 35: 144-150. (SCI)

10.    Kuo MYP, Lin CY, Hahn LJ, Chiang CP. 1999. Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 28:165-169. (SCI)  (corresponding author)

11.    Chiang CP, Huang JS, Wang JT, Liu BY, Kuo YS, Hahn LJ, Kuo MYP. 1999. Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking-associated oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 28:72-76. (SCI)

12.    Kuo MYP, Huang JS, Hsu HC, Chiang CP, Kok SH, Kuo YS, Hong CY. 1999. Infrequent p53 mutations in patients with areca quid chewing-associated oral squamous cell carcinomas in Taiwan. J Oral Pathol Med 28:221-225. (SCI)

13.    Sun A, Wu YC, Wang JT, Liu BY, Chiang CP. 2000. Association of HLA-Te22 antigen with anti-nuclear antibodies in Chinese patients with erosive lichen planus. Proc Natl Sci Council, ROC 24:63-9.  (corresponding author)

14.    Chiang CP, Lang MJ, Liu BY, Wang JT, Leu JS, Hahn LJ, Kuo MYP. 2000. Expression of p53 protein in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia.  J Formos Med Assoc 99:229-34. (SCI)

15.    Sun A, Hsieh RP, Liu BY, Wang JT, Wu YC, Chiang CP. 2000. Strong association of anti-epithelial cell antibodies with HLA-DR3 or DR7 phenotype in patients with recurrent oral ulcers. J Formos Med Assoc 99:290-4. (SCI)  (corresponding author)

16.    Sun A, Chu CT, Liu BY, Wang JT, Leu JS, Chiang CP. 2000. Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proc Natl Sci Council, ROC, Part B: Life Sciences 24:116-22.  (corresponding author)

17.    Lin SK, Hong CY, Chang HH, Chiang CP, Chen CS, Jeng JH, Kuo MYP. 2000. Immunolocalization of macrophages and transforming growth factor-b1 in induced rat periapical lesions. J Endod 26:335-40. (SCI)

18.    Chiang CP, Lang MJ, Liu BY, Wang JT, Leu JS, Hahn LJ, Kuo MYP. 2000. Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. Oral Oncol 36:353-9. (SCI)

19.    Liu BY, Wang JT, Leu JS, Chiang CP, Hsieh CC, Kwan HW. 2000. Effects of continuous calcitonin treatment on osteoclasts derived from cocultures of mouse marrow stromal and spleen cells. J Formos Med Assoc 99:140-50. (SCI)

20.    Chen SK, Chang HF, Chiang CP, Wang JS, Lan WH, Hsieh CC. 2000. Three-year evaluation of problem-based learning in oral radiology team teaching. J Med Edu 4:155-62.

21.    Ho TJ, Chiang CP, Hong CY, Kok SH, Kuo YS, Kuo MYP. 2000. Induction of the c-jun protooncogene expression by areca nut extract and arecoline on oral mucosal fibroblasts. Oral Oncol 36:432-6. (SCI)

22.    Sun A, Hsieh RP, Chu CT, Wang JT, Liu BY, Chiang CP. 2001. Some specific HLA DR/DQ haplotypes are more important than individual HLA-DR and -DQ phenotypes for development of mucocutaneous type of Behcet's disease and for disease shift from recurrent aphthous stomatitis to mucocutaneous type of Behcet’s disease. J Oral Pathol Med 30:402-7. (SCI) (corresponding author)

23.    Chen CH, Liu BY, Wang JT, Sun A, Leu JS, Chiang CP. 2001. Expression of epidermal growth factor in salivary adenoid cystic carcinoma. Proc Natl Sci Council, ROC, Part B: Life Sciences 2001;25:90-6. (corresponding author).

24.    Huang JS, Ho TJ, Chiang CP, Kok SH, Kuo YS, Kuo MYP. 2001. MDM 2 expression in areca quid chewing-associated oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 30:53-8. (SCI)

25.    Tai YS, Liu BY, Wang JT, Sun A, Kwan HW, Chaing CP. 2001. Oral administration of immune milk from cow immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis. J Oral Pathol Med 30:618-25. (SCI) (corresponding author)

26.    Chen CT, Tsai T, Chiang CP. 2001. Photodynamic diagnosis and therapy in the   management of oral neoplasia. N Taipei J Med 3:1-5.

27.    Chen SK, Chang HF, Chiang CP. 2001. Group learning factors in a problem-based course in oral radiology. Dentomaxillofac Radiol 30:84-7.

28.    Chiang CP, Chen CH, Liu BY, Sun A, Leu JS, Wang JT. 2001. Expression of transforming growth factor-α in adenoid cystic carcinoma of the salivary gland. J Formos Med Assoc 100:471-7. (SCI)

29.    Lin SK, Wang CC, Huang S, Lee JJ, Chiang CP, Lan WH, Hong CY. 2001. Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1α and tumor necrosis factor-α through a prostaglandin-dependent pathway. J Endod 27:185-9. (SCI)

30.    Huang GF, Lan WH, Guo MK, Chiang CP. 2001. Synergistic effect of Nd:YAG laser combined with fluoride varnish on inhibition of caries formation in dental pits and fissures in vitro. J Formos Med Assoc 100:181-5. (SCI)

31. Sun A, Chiang CP. 2001. Levamisole and/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus. J Oral Pathol Med 30:542-8. (SCI) (corresponding author)

32. Chiu CJ, Chiang CP, Chang ML, Chen HM, Hahn LJ, Hsieh LL, Kuo YS, Chen CJ. 2001. Association between genetic polymorphism of tumor necrosis factor-α and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer. J Dent Res 80:2055-9. (SCI)

33. Chiang CP, Wu HY, Liu BY, Wang JT, Kuo MYP. 2002. Quantitative analysis of  immunocompetent cells in oral submucous fibrosis in Taiwan. Oral Oncol 38:52-63. (SCI)

34. Chiu CJ, Lee WC, Chiang CP, Hahn LJ, Kuo YS, Chen CJ. 2002. A scoring system for the early detection of oral submucous fibrosis based on a self-administered questionnaire. J Pub Heal Dent 62:28-31. (SCI)

35. Kuo MYP, Hsu HY, Kok SH, Kuo RC, Yang H, Hahn LJ, Chiang CP. 2002. Prognostic role of p27Kip1 expression in oral squamous cell carcinoma in Taiwan. Oral Oncol 38:172-8. (SCI) (corresponding author)

36. Kuo MYP, Huang JS, Kok SH, Kuo YS, Chiang CP. 2002. Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan. J Oral Pathol Med 31:16-22. (SCI) (corresponding author)

37. Sun A, Chia JS, Chang YF, Chiang CP. 2002. Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus. J Oral Pathol Med 31:196-203. (SCI) (corresponding author)

38. Kok SH, Lee JJ, Hsu HC, Chiang CP, Kuo YS, Kuo MYP. 2002. Mutations of the adenomatous polyposis coli gene in areca quid and tobacco-associated oral squamous cell carcinma. J Oral Pathol Med 31:395-401.

39. Chiang CP, Hsieh RP, Chen THH, Chang YF, Liu BY, Wang JT, Sun A, Kuo MYP. 2002. High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis. J Oral Pathol Med 31:402-9. (SCI)

40. Sun A, Chia JS, Chiang CP. 2002. Increased proliferation response of peripheral blood mononuclear cells and T cells to Streptococcus mutans and glucosyltransferase D antigens in the exacerbation stage of recurrent aphthous ulcerations. J Formos Med Assoc 101:560-6. (SCI) (corresponding author)

41. Chiu CJ, Chang ML, Chiang CP, Hahn LJ, Hsieh LL, Chen CJ. 2002. Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. Cancer Epidemiol Biom Prev 11:646-53.

42. Wang CY, Tsai TM, Chen HM, Chang SC, Chen CT, Chiang CP. 2003. Autofluorescence spectroscopy for in vivo diagnosis of DMBA-induced hamster bucccal pouch precancers and cancers. J Oral Pathol Med 32:18-24. (SCI) (corresponding author)

43. Wang CY, Tsai TM, Chen HM, Chen CT, Chiang CP. 2003. PLS-ANN based classification model for Oral submucous fibrosis and oral carcinogenesis. Lasers Surg Med 32:318-326. (SCI) (corresponding author)

44. Chen HM, Kuo MYP, Lin KH, Lin CY, Chiang CP. 2003. Expression of cyclin A is correlated with the progression of oral squamous cell carcinoma in Taiwan. Oral Oncol 39:476-482. (SCI) (corresponding author)

45. Sun A, Chia JS, Chang YF, Chiang CP. 2003. Levamisole and Chinese medicinal herbs can modulate the serum interleukin-6 level in patients with recurrent aphthous ulcerations. J Oral Pathol Med (in press) (SCI) (corresponding author)

46. Chen HM, Wang CY, Chen CT, Yang H, Kuo YS, Lan WH, Kuo MYP, Chiang CP. 2003. Autofluorescence spectra of oral submucous fibrosis. J Oral Pathol Med (in press) (SCI) (corresponding author)

47. Wang YP, Chang YF, Wang JT, Liu BY, Sun A, Chiang CP. 2003. Calcifying odontogenic cyst: a clinicopathologic study of 10 cases. J Formos Med Assoc (in press) (SCI) (corresponding author)

48. Chen HM, Shih CC, Yen KL, Wang SM, Kuo YS, Kuo MYP, Chiang CP. Facial Candida albicans cellulites occurring in a patient with oral submucous fibrosis and unknown diabetes mellitus after local corticosteroid injection treatment. J Oral Pathol Med (in press) (SCI) (corresponding author)

49. Chen HM, Hsieh RP, Yang H, Kuo YS, Kuo MYP, Chiang CP. HLA typing in Taiwanese patients with oral submucous fibrosis. J Oral Pathol Med (in press) (SCI) (corresponding author)

50. Chang JYF, Lin MC, Chiang CP. High-risk human papillomaviruses may play an important role in non-oral habits associated oral squamous cell carcinomas in Taiwan. J Am J Clin Pathol (in press) (SCI) (corresponding author)

51. Chang JYF, Wang JT, Wang YP, Liu BY, Sun A, Chiang CP. Odontoma: a clinicopathologic study of 81 cases. J Formos Med Assoc (in press) (SCI) (corresponding author)

 

 

CONFERENCE PAPERS:

 

1.      Chiang CP. 1998. Oral mucosal lesions in betel nut chewers. The 21th Annual Scientific Meeting of the Association for Dental Sciences, ROC. Chin Dent J 17:31.

2.      Kuo MYP, Chiang CP, Hahn LJ. 1998. Molecular biology studies of areca quid chewing-related oral squamous cell carcinomas in Taiwan. The 91st annual meeting of Formosan Medical Association, Republic of China. p. 100-101.

3.      Huang KF, Kuo MK, Chiang CP, Lan WH. 1998. Effect of laser irradiation on pit and fissure caries. The 91st annual meeting of Formosan Medical Association, Republic of China. p. 95-96.

4.      Sun A, Chiang CP, Hsieh LP, Chu CT. 1998.  Genetic linkage of HLA-DR/DQ haplotypes in Chinese patients with mucocutaneous type of Behcet's disease or recurrent oral ulcers.  Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 16.

5.      Chiang CP, Wang JT, Liu BY. 1998. Clinical Oral Pathology Conference - Case Report. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 27.

6.      Chiang CP, Wang JT, Liu BY, Kwan HW. 1999. Clinical Oral Pathology Conference - Case Report. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 17.

7.      Chiang CP, Wang JT, Liu BY, Kwan HW. 2000. Clinical Oral Pathology Conference - Case Report. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 17.

8.      Choa IG, Chiang CP. 2001. Expression of p53, p21 and MDM2 proteins and PCNA in odontogenic cysts. The 23rd Asia Pacific Dental Congress and the 13th Annual Scientific Meeting and General Assembly of ADS-ROC. p. 219.

9.      Lai JI, Chiang CP. Quantitative analysis of microvessels in oral premalignant lesions and squamous cell carcinomas. 2001. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 15.

10.  Chiang CP, Chang YF, Liu BY, Wang JT, Sun A, Kwan SW. 2001. High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 17.

11.  Chiang CP, Wang JT, Liu BY, Kwan HW. 2001. Clinical Oral Pathology Conference - Case Report. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 22.

12.  Chiang CP, Tsai TM, Wang CY, Chen HM, Chen CT. 2002. Autofluorescence spectroscopy for in vivo diagnosis of oral submucous fibrosis, oral premalignant lesions and oral cancers. 2002 BioPhotonics Symposium. p. 53-58.

13.  Chiang CP. 2002. Light-induced fluorescence spectroscopy: a potential diagnostic tool for oral cancers and precancerous lesions. The 24th Asia Pacific Dental Congress and The 44th KDA Scientific Congress. p.79

14.  Pan JH, Kuo MYP, Chiang CP, Hahn LJ. 2002. The distribution of CD95/CD95L in oral squamous cell carcinoma in Taiwan. The 25th Annual Scientific Meeting of the Association for Dental Sciences, ROC. Chin Dent J 21:54.

15.  Chiang CP, Wang JT, Liu BY, Kwan HW. 2002. Clinical Oral Pathology Conference - Case Report. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 41.

16.  Chiang CP. 2002. Photodynamic diagnosis and therapy for oral precancers and cancers. Annual Meeting of the Academy of Oral Pathology, Republic of China. p. 12.

 

OTHERS:

 

1.      Hong-Pin Lin. Expression of p53, MDM-2, p21, heat shock and HPV 16/18 E6 proteins in oral verrucous carcinoma and verrucous hyperplasia. 1998. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

2.      Jehn-Shyun Huang. The expression and mutation of tumor suppressor genes p53, APC and MCC in oral squamous cell carcinomas of Taiwan. 1999. Ph.D. Dissertation (Chun-Pin Chiang as sponsor and advisor)

3.      Hong-Yan Sheu. Expression of p27 gene product in oral squamous cell carcinoma. 1999. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

4.      Meng-Lin Chiang. Expression of apoptosis-associated proteins in oral premalignant lesions and squamous cell carcinomas. 2000. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

5.      In-Gow Choa. Expression of p53, p21, MDM2 and PCNA in odontogenic keratocysts, dentigerous cysts and radicular cysts. 2001. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

6.      Jyh-I Lai. Quantitative analysis of microvessels in oral premalignant lesions and squamous cell carcinomas. 2001. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

7.      Kai-Hung Lin. Prognostic role of cyclin A expression in oral squamous cell carcinoma. 2002. Master Thesis (Chun-Pin Chiang as sponsor and advisor)

  

C. 研究計畫

補助單位

        

計畫編號

執行期限

國科會

p53, p21, MDM2 和增殖細胞和抗原(PCNA) 於齒源性囊腫之表現

NSC89-2314-B-002-167

88/8/1-89/7/31

國科會

細胞凋亡相關蛋白於口腔癌前病變及鱗狀細胞癌之表現

NSC89-2314-B-002-361

89/8/1-90/7/31

國科會

光電科技支螢光光譜應用於診斷口腔癌前病變及口腔癌之系列研究總計畫(1/3)

NSC89-2736-L-002-005

89/1/1-89/12/31

國科會

光電科技支螢光光譜應用於診斷口腔癌前病變及口腔癌之系列研究子計畫:螢光光譜用於診斷倉鼠頰袋囊癌前即癌病變之活體研究(I)

NSC89-2736-L-002-006

89/1/1-89/12/31

國科會

光電科技之螢光光譜應用於診斷口腔癌前病變及口腔癌之系列研究總計畫(II)

NSC90-2736-L002-002

90/1/1-90/12/31

國科會

光電科技之螢光光譜應用於診斷口腔癌前病變及口腔癌之系列研究---子計畫

NSC90-2736-L002-003

90/1/1-90/12/31

國科會

肝細胞生長因子及其受氣器 c-met 蛋白於口腔癌前病變及鱗狀細胞癌之表現

NSC91-2314-B002-150  

91/8/1-92/7/31