台大醫學院法醫學科暨法醫學研究所
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陳珮珊 副教授 (Pai-Shan Chen)
一、研究計畫

Research area: Liquid and solid microextraction; Separation of biological molecules; Small molecule

metabolism; Mass spectrometry; Mass based Metabolomics.

 

A major toxicological challenge is distinguishing whether urine containing morphine, but no 6-monoacetylmorphine (6-MAM), originates from ‘street’ heroin use or poppy seed ingestion.  Heroin is synthesized by acetylation of morphine.  Thebaine, also present in opium, is likewise acetylated but also undergoes skeletal rearrangement, involving production of a 2-(N-methy1acetamido)ethyl side chain.  The hypothesis that this tertiary amide is resistant to endogenous hydrolysis was supported from in-vitro experiments and a metabolite was identified that may be used as a signature of ‘street’ heroin.  It was detected in known heroin users’ urine that had tested negative for 6-MAM but positive for morphine.


 

二、期刊論文

[1]        S.-P. Chu, C.-K. Huang, P.-S. Chen, S.-D. Huang, Two dispersive liquid–liquid microextraction methods coupled with gas chromatography–mass spectrometry for the determination of organophosphorus pesticides in field water, Environmental Chemistry (2014) in press.

[2]        P. Chen, R.A. Braithwaite, C. George, P.J. Hylands, M.C. Parkin, N.W. Smith, A.T. Kicman, The poppy seed defense: a novel solution, Drug Testing and Analysis 6 (2014) 194.

[3]        W.-C. Tseng, S.-P. Chu, P.-H. Kong, C.-K. Huang, J.-H. Chen, P.-S. Chen, S.-D. Huang, Water with low concentration of surfactant in dispersed solvent-assisted emulsion dispersive liquid–liquid microextraction for the determination of fungicides in wine, Journal of Agricultural and Food Chemistry 62 (2014) 9059.

[4]        P.-S. Chen, W.-Y. Haung, S.-D. Huang, Analysis of triazine herbicides using an up-and-down-shaker-assisted dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry, Journal of Chromatography B 955–956 (2014) 116.

[5]        W.-C. Tseng, P.-S. Chen, S.-D. Huang, Optimization of two different dispersive liquid–liquid microextraction methods followed by gas chromatography–mass spectrometry determination for polycyclic aromatic hydrocarbons (PAHs) analysis in water, Talanta 120 (2014) 425.

[6]        K.-D. Wang, P.-S. Chen, S.-D. Huang, Simultaneous derivatization and extraction of chlorophenols in water samples with up-and-down shaker-assisted dispersive liquid–liquid microextraction coupled with gas chromatography/mass spectrometric detection, Analytical and Bioanalytical Chemistry 406 (2014) 2123.

[7]        Y. Li, P.-S. Chen, S.-D. Huang, Water with low concentration of surfactant in dispersed solvent-assisted emulsion dispersive liquid–liquid microextraction for the determination of organochlorine pesticides in aqueous samples, Journal of Chromatography A 1300 (2013) 51.

[8]        L.-H. Li, M.-Y. Yen, C.-C. Ho, P. Wu, C.-C. Wang, P.K. Maurya, P.-S. Chen, W. Chen, W.-Y. Hsieh, H.-W. Chen, Non-Cytotoxic nanomaterials enhance antimicrobial activities of cefmetazole against multidrug-resistant <italic>Neisseria gonorrhoeae</italic>, PLoS ONE 8 (2013) e64794.

[9]        P.-S. Chen, S.-P. Huang, M.-R. Fuh, S.-D. Huang, Determination of organochlorine pesticides in water using dynamic hook-type liquid-phase microextraction, Analytica Chimica Acta 647 (2009) 177.

[10]       S.-P. Huang, P.-S. Chen, S.-D. Huang, Dynamic headspace time-extended helix liquid-phase microextraction, Journal of Chromatography A 1216 (2009) 4347.

[11]       P.-S. Chen, S.-D. Huang, Coupled two-step microextraction devices with derivatizations to identify hydroxycarbonyls in rain samples by gas chromatography–mass spectrometry, Journal of Chromatography A 1118 (2006) 161.

[12]     P.-S. Chen, S.-D. Huang, Determination of ethoprop, diazinon, disulfoton and fenthion using dynamic hollow fiber-protected liquid-phase microextraction coupled with gas chromatography–mass spectrometry, Talanta 69 (2006) 669.