專任教師 English

 

莊雅惠老師

學歷

 

台大醫事技術學系 學士
台大免疫學研究所 碩士
台大免疫學研究所 博士
美國加州大學戴維斯分校博士後研究

職稱

台大醫學檢驗暨生物技術學系 助理教授
國立臺灣大學附設醫院檢驗醫學部 兼任醫檢師

 

學會

中華民國免疫學會

 

Email:yahuichuang@ntu.edu.tw

 

電話:02-23123456轉66906

 

老師的話

The difference between the impossible and possible lies in a person’s determination.

 

研究主題

免疫細胞或細胞激素在過敏氣喘疾病之角色

免疫細胞或細胞激素在自體免疫疾病之角色

建立自體免疫疾病之動物模式及研究其致病機轉

 

實驗室成員

研究助理: 姿君
碩士班研究生: 希傑、曉玉、佑儒、肇軒、盈君
 

Publication (in the past 5 years)

1.

YH Yang, CF Hung, CR Hsu, LC Wang, YH Chuang, YT Lin and BL Chiang*. A nationwide survey on epidemiological characteristics of childhood Henoch–Schonlein purpura in Taiwan. Rheumatology 2005; 44: 618-622. (SCI)

2.

YH Yang, YH Huang, YH Chuang, CM P, LC Wang, YT Lin and BL Chiang*. Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome (SARS)-associated coronavirus infection. J. Med. Virol. 2005; 77: 1-7. (SCI)

3.

YH Chuang, ZX Lian, CM Cheng, RY Lan, GX Yang, Y Moritoki, BL Chiang, AA Ansari, K Tsuneyama, RL Coppel and ME Gershwin*. Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives. J. Autoimmunol. 2005; 25: 126-32. (SCI)

4.

RY Lan, CM Cheng, ZX Lian, K Tsuneyama, GX Yang, Y Moritoki, YH Chuang, T Nakamura, S Saito, S Shimoda, A Tanaka, CL Bowlus, Y Takano, AA Ansari, RL Coppel, and ME Gershwin*. Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology 2006; 43: 729-37. (SCI)

5.

YH Chuang, JL Suen and BL Chiang*. Fas-ligand-expressing adenovirus-transfected dendritic cells decrease allergen-specific T cells and airway inflammation in a murine model of asthma. J. Mol. Med. 2006; 84: 595-603. (SCI)

6.

YH Yang, YH Huang, YL Lin, LC Wang, YH Chuang, HH Yu, YT Lin and BL Chiang*. Circulating IgA from acute stage of childhood Henoch-Schonlein purpura can enhance endothelial interleukin (IL)-8 production through MEK/ERK signalling pathway. Clin. Exp. Immunol. 2006; 144: 247-53. (SCI)

7.

CC Wang, CL Fu, YH Yang, YC Lo, LC Wang, YH Chuang, DM Chang and BL Chiang*. Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther. 2006; 13: 1414-21. (SCI)

8.

YH Chuang, ZX Lian, K Tsuneyama, BL Chiang, AA Ansari, RL Coppel and ME Gershwin*. Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J. Autoimmunol. 2006; 26: 232-40. (SCI)

9.

S Oertelt, ZX Lian, CM Cheng, YH Chuang, KA Padgett, XS He, WM Ridgway, AA Ansari, RL Coppel, MO Li, RA Flavell, M Kronenberg, IR Mackay, and ME Gershwin*. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-ß receptor II dominant-negative mice. J. Immunol. 2006; 177: 1655-60. (SCI)

10.

K Wakabayashi, ZX Lian, Y Moritoki, RY Lan, K Tsuneyama, YH Chuang, GX Yang, W Ridgway, AA Ansari, RL Coppel, IR Mackay and ME Gershwin*. IL2Ra-/- mice and the development of primary biliary cirrhosis. Hepatology. 2006; 44:1240-49. (SCI)

11.

CL Fu, YH Chuang, LY Chau, and BL Chiang*. Effects of Adenovirus-Expressing IL-10 in Alleviating Airway Inflammation in Asthma. J Gene Med. 2006; 8:1393-99. (SCI)

12.

Y Moritoki, ZX Lian, H Wulff, GX Yang, YH Chuang, RY Lan, Y Ueno, AA Ansari, RL Coppel, IR Mackay, and ME Gershwin*. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology 2007; 45: 314-22. (SCI)

13.

S Shu, ZX Lian, YH Chuang, GX Yang, Y Moritoki, SS Comstock, RQ Zhong, AA Ansari, YJ Liu, and ME Gershwin*. The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses.Clin Exp Immunol. 2007; 149: 335-43. (SCI)

14.

GX Yang, ZX Lian, YH Chuang, SA Shu, Y Moritoki, R Lan, K Wakabayashi, AA Ansari, K Dorshkind, S Ikehara, and ME Gershwin*. Generation of functionally distinct B lymphocytes from common myeloid progenitors. Clin Exp Immunol. 2007; 150: 349-57. (SCI)

15.

YH Chuang, ZX Lian*, GX Yang, SA Shu, Y Moritoki, WM Ridgway, AA Ansari, M Kronenberg, RA Flavell, B Gao, and ME Gershwin. Natural killer T cells exacerbate liver injury in a transforming growth factor b receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology 2008; 47:571-80. (SCI)

16.

YH Yang, YH Chuang, LC Wang, HY Huang, ME Gershwin and BL Chiang*. The immunobiology of Henoch–Schönlein purpura. Autoimmunity Reviews 2008; 7:179-184. Review (SCI)

17.

GX Yang, ZX Lian, YH Chuang, Y Moritoki, RY Lan, K Wakabayashi, AA Ansari, RA Flavell, WM Ridgway, RL Coppel, K Tsuneyama, IR Mackay, and ME Gershwin*. Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice.Hepatology 2008; 47:1974-1982.(SCI)

18.

PS Leung, YS Lee, CY Tang, WY Kung, YH Chuang, BL Chiang, MC Fung, and KH Chu*. Induction of Shrimp Tropomyosin-Specific Hypersensitivity in Mice. Int Arch Allergy Immunol. 2008; 147: 305-314. (SCI)

19.

CL Fu, YH Chuang, HY Huang, and BL Chiang*. Induction of IL-10 producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells. Clin Exp Immunol. 2008; 153:258-68. (SCI)

20.

HX Wei, YH Chuang, B Li, H Wei, R Sun, Y Moritoki, ME Gershwin, ZX Lian*, and Z Tian*. CD4+CD25+Foxp3+ Regulatory T Cells Protect against T Cell-Mediated Fulminant Hepatitis in a TGF-b-Dependent Manner in Mice. J. Immunol. 2008; 181: 7221-7229. (SCI)

21.

YH Chuang, WM. Ridgway, Y Ueno and ME Gershwin*. Animal models of primary biliary cirrhosis. Clin Liver Dis. 2008; 12 (2): 333-47. review

22. YH Chuang, YH Yang, SJ Wu, and BL Chiang*. Gene therapy for allergic diseases. Curr. Gene Ther. 2009; 9(3):185-191. (SCI) Review
23. YH Chuang, RY Lan, and ME Gershwin*. The Immunopathology of Human Biliary Cell Epithelium. Semin. Immunopathol. 2009; 31(3): 323-331 (SCI) Review

24.

YH Yang, CJ Chang, YH Chuang, HY Hsu, PP Chen, BL Chiang*. Identification of anti-prothrombin antibodies in the antiphospholipid syndrome that display the prothrombinase activity. Rheumatology. 2009 (in press) (SCI)