專任教師 English

 

俞松良老師

學歷

國立臺灣大學醫學院醫事技術學系 學士

國立臺灣大學醫學院醫事技術研究所 碩士

國立陽明大學微生物及免疫學研究所 博士

 

職稱

國立臺灣大學醫學檢驗暨生物技術學系
教授

國立臺灣大學附設醫院檢驗醫學部
兼任醫檢師

 

Email:slyu@ntu.edu.tw

 

電話:02-23123456轉88697

 

研究主題

基因體學

腫瘤醫學

微生物學

肺癌是最常見引起死亡的癌症。但是,目前臨床病理分期方法對肺癌治療預後的預測並不準確。因此,我們希望由基因層次探討癌生成與轉移的機制、發展癌症標記及預測肺癌病人的復發與存活率,最終找出癌症標記,並針對個別病人的狀況進行個人化醫療評估。微核醣核酸是一類新的小核醣核酸,其扮演負向性的基因調節功能,在腫瘤學研究中,微核醣核酸的表現剖繪與訊息核醣核酸皆可準確地進行癌症亞型分類。因此,我們針對肺癌病患的微核醣核酸表現進行研究,是否其表現可以用於預測肺癌病患治療後的存活率。該技術可應用於癌症分子病理學的研究或新標把性治療的開發,更可進一步發展成檢測用套組,以用於評估病患預後效果,並可有助於選擇高風險的癌症病人,在早期即進行輔佐性化療,或給予更進一步的治療。

 

代表著作 (2008-2013)
  1. Yu SL, Hsuan-Yu Chen, Gee-Chen Chang, Chih-Yi Chen, Huei-Wen Chen, Sher Singh, Chiou-Ling Cheng, Chong-Jen Yu, Yung-Chie Lee, Han-Shiang Chen, Te-Jen Su, Ching-Cheng Chiang, Han-Ni Li, Qi-Sheng Hong, Hsin-Yuan Su, Chun-Chieh Chen, Wan-Jiun Chen, Chun-Chi Liu, Wing-Kai Chan, Wei J. Chen, Ker-Chau Li, Jeremy J.W. Chen, and Pan-Chyr Yang. (2008) MicroRNA Signature Predicts Survival and Relapse in Lung Cancer. Cancer cell 1; 48-57 (SCI). (Original article).
  2. Yu SL, Sher Singh, PhD, Huei-Wen Chen, Hsuan-Yu Chen, Jeremy J.W. Chen, PhD, Wen-Jone Chen, Han-Shiang Chen, Shyr-Chyr Chen. (2008) Intra-abdominal Adhesion Formation Induces Anti-oxidative Injury, Enhances Cell Proliferation, and Prevents Complement-mediated Lysis. Wound Repair and Regeneration (16(3):388-98.) (SCI). (Original article).
  3. Chen HW, Jen-Yi Lee, Ji-Ying Huang, Chi-Chung Wang , Wan-Jiun Chen, Sheng-Fang Su, Chia-Wen Huang, Chao-Chi Ho, Meng-Feng Tsai, Sung-Liang Yu, Jeremy JW Chen, and Pan-Chyr Yang (2008) Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1 Cancer Research 68; 7428-38. (SCI). (Original article).
  4. Yu-Chih Chao, Szu-Hua Pan, Shuenn-Chen Yang, Sung-Liang Yu, Che-Hsiang Wu, Chung-Wu Lin, Mu-shiun Tsai, Gee-Chen Chang, Ting-Fang Che, Yi-Ying Wu, Tse-Ming Hong, and Pan-Chyr Yang. (2009) Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma. Am. J. Respir. Crit. Care Med. 179; 123-33. (SCI). (Original article).
  5. Wan-Hsin Liu, Shiou-Hwei Yeh, Cho-Chun Lu, Sung-Liang Yu, Hsuan-Yu Chen, Chien-Yu Lin, Ding-Shinn Chen and Pei-Jer Chen. (2009) Elevation of MicroRNA-18a Downregulates Estrogen Receptor Alpha and Stimulates Hepatocyte Proliferation in Female Hepatocellular Carcinoma. Gastroenterology. 136; 683-93. (SCI). (Original article).
  6. Steven Shoei-Lung Li, Sung-Liang Yu, Li-Pin Kao, Zong Yun Tsai, Sher Singh, Bo Zhi Chen, Bing-Ching Ho, Yung-Hsien Liu and Pan-Chyr Yang. (2009) Target identification of microRNAs expressed highly in human embryonic stem cells. Journal of Cellular Biochemistry. 106; 1020-30. (SCI). (Original article).
  7. Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. (2009) Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-kappaB Pathways. J Med Chem. Mar 13. [Epub ahead of print] (SCI). (Original article).
  8. Kao LP, Yu SL, Singh S, Wang KH, Kao AP, and Li SSL. 2009. Comparative Profiling of mRNA and microRNA Expression in Human Mesenchymal Stem Cells Derived from Adult Adipose and Lipoma Tissues. The Open Stem Cell Journal. 1(9):1-9. (equal contribution) (Original article).
  9. Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, Wang DS, Lu YS, Hsu C, Cheng AL. 2009. Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res. 15:5820-8.
  10. Zong-Yun Tsai, Sher Singh, Sung-Liang Yu, Li-Pin Kao, Bo-Zhi Chen, Bing-Ching Ho, Pan-Chyr Yang and Steven Shoei-Lung Li. (2010) Identification of microRNAs regulated by activin A in human embryonic stem cells. Journal of Cellular Biochemistry. 109:93-102.
  11. Hsu YC, Yuan S, Chen HY, Yu SL, Liu CH, Hsu PY, Wu G, Lin CH, Chang GC, Li KC, Yang PC. (2009) A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non-Small Cell Lung Cancer. Clin Cancer Res. 15: 7309-7315.
  12. Yu, Yung-Luen*; Yu, Sung-Liang*; Su, Kuo-Jung; Wei, Chyou-Wei; Jian, Min-Hui; Lin, Po-Cheng; Tsen, I-Hsuan; Lin, Chai-Ching; Su, Chin-Cheng; Chang, Wen-Liang; Lin, Shinn-Zong; Harn, Horng-Jyh; Chen, Yi-Lin. (2010) Extended MGMT promoter hypermethylation following n-Butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of HCC carcinoma cells growth. Journal of Agricultural and Food Chemistry 58: 1630-1638. (equal contribution). (SCI). IF: 2.562 (2/35)
  13. Tzu-Pei Chang*, Sung-Liang Yu *, Sheng-Yi Lin, Yi-Jing Hsia, Gee-Chen Chang, Pan-Chyr Yang, Jeremy J.W. Chen (2010) Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation. Cancer Research 15: 1656-1667. (equal contribution). (SCI). IF: 7.514 (12/143)
  14. Yang YL, Lin SR, Chen JS, Lin SW, Yu SL, Chen HY, Yen CT, Lin CY, Lin JF, Lin KH, Jou ST, Hu CY, Chang SK, Lu MY, Chang HH, Chang WH, Lin KS, Lin DT. (2010) Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leukemia Research 34: 18-23. (SCI).
  15. Chen PM, Chen YY, Yu SL, Sher S, Lai CH, Chia JS (2010) GlnR-mediated acid-repression of glutamine/glutamate metabolism clusters in Streptococcus mutans. Applied and Environmental Microbiology 76: 2478-2486 (SCI).
  16. Wang KH, Kao AP, Singh S, Yu SL, Kao LP, Tsai ZY, Lin SD, Li SS. (2010) Comparative expression profiles of mRNAs and microRNAs among human mesenchymal stem cells derived from breast, face, and abdominal adipose tissues. Kaohsiung J Med Sci. 26:113-22.
  17. Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM, Yu SL, Chen JS, Chang KJ, Jee SH, Tan CT, Lin MT, Kuo ML. (2010) MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1{alpha} Expression and Tumor Angiogenesis. Cancer Res. 70: 2675-2685.
  18. Lin SY, Hsueh CM, Yu SL, Su CC, Shum WY, Yeh KC, Chang GC, Chen JJ. (2010) HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma. Nucleic Acids Res. 38:6148-58
  19. Chen BZ*, Yu SL*, Singh S, Kao LP, Tsai ZY, Yang PC, Chen BH, Li SS. (2011) Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells. Cell Biol Int. 35:29-37 (Chen BZ and Yu SL equal contribution)
  20. Yang YL, Lin SR, Chen JS, Hsiao CC, Lin KH, Sheen JM, Cheng CN, Wu KH, Lin SW, Yu SL, Chen HY, Lu MY, Chang HH, Yen CT, Lin JF, Su YH, Li YP, Lin CY, Jou ST, Lin DT. (2010) Multiplex reverse transcription-polymerase chain reaction as diagnostic molecular screening of 4 common fusion chimeric genes in Taiwanese children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 32:e323-30.
  21. Lin PY, Yu SL*, Yang PC* (2010) MicroRNA in lung cancer. Br J Cancer. 103:1144-8. Review. (Yu SL and Yang PC equal contribution).
  22. Tsai ZY, Singh S, Yu SL, Chou CH, Li SS. (2010) A feeder-free culture using autogeneic conditioned medium for undifferentiated growth of human embryonic stem cells: comparative expression profiles of mRNAs, microRNAs and proteins among different feeders and conditioned media. BMC Cell Biol. 11:76.
  23. Chang TH, Tsai MF, Su KY, Wu SG, Huang CP, Yu SL, Yu YL, Lan CC, Yang CH, Lin SB, Wu CP, Shih JY, Yang PC. (2010) Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. Am J Respir Crit Care Med. 2010 Oct 29. [Epub ahead of print]
  24. Yu SL, Lin SB, Yu YL, Chien MH, Su KJ, Lin CJ, Way TD, Yiang GT, Lin CC, Chan DC, Harn HJ, Chen YL. (2010) Isochaihulactone protects PC12 cell against H(2)O(2) induced oxidative stress and exerts the potent anti-aging effects in D-galactose aging mouse model. Acta Pharmacol Sin. 31:1532-40
  25. Ou DL, Shen YC, Yu SL, Chen KF, Yeh PY, Fan HH, Feng WC, Wang CT, Lin LI, Hsu C, Cheng AL. (2010) Induction of DNA Damage-Inducible Gene GADD45{beta} Contributes to Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Cells. Cancer Res. 70:9309-18.
  26. Li SS, Yu SL, Singh S. (2010) Epigenetic states and expression of imprinted genes in human embryonic stem cells. World J Stem Cells 2:97-102.
  27. Bing-Ching Ho*, Sung-Liang Yu*, Jeremy J.W. Chen, Sui-Yuan Chang, Bo-Shiun Yan, Qi-Sheng Hong, Sher Singh, Chuan-Liang Kao, Hsuan-Yu Chen, Kang-Yi Su, Ker-Chau Li, Chiou-Ling Cheng, Hao-Wei Cheng, Jen-Yi Lee, Chun-Nan Lee and Pan-Chyr Yang (2011) Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host & Microbe 20:58-69. (Ho BC and Yu SL equal contribution)
  28. Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH. (2011) Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action. Bioorg Med Chem. 19: 1816-1822.
  29. Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH. (2011) Antitumor Agents 288. Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogs as Potent and Selective Antitumor Agents. J Med Chem. 54:5097-107.
  30. Lai CY, Yu SL, Hsieh MH, Chen CH, Chen HY, Wen CC, Huang YH, Hsiao PC, Hsiao CK, Liu CM, Yang PC, Hwu HG, Chen WJ. (2011) MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. PLoS One. 6:e21635.
  31. Shinsheng Yuan, Sung-Liang Yu, Hsuan-Yu Chen, Yi-Chiung Hsu, Kang-Yi Su, Huei-Wen Chen, Chih-Yi Chen, Chong-Jen Yu, Jin-Yuan Shih, Yung-Chie Lee, Yih-Leong Chang,  Chiou-Ling Cheng,  Chung-Ping Hsu, Jiun-Yi Hsia, Chien–Yu Lin, Guani Wu, Chia-Hsin Liu, Chin-Di Wang, Kang-Chung Yang, Yi-Wei Chen, Yi-Ling Lai, Chu-Chun Hsu, Tai-Jing Lin, Tsung-Ying Yang, Kun-Cheieh Chen, Kuo-Hsuan Hsu, Jeremy J.W. Chen, Gee-Chen Chang , Ker-Chau Li, and Pan-Chyr Yang. (2011) Clustered Genomic Alterations in Chromosome 7p Dictate Outcomes and Targeted Treatment Responses of Lung Adenocarcinoma with EGFR-activating Mutations. Journal of Clinical Oncology. 29:3435-42.
  32. Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW, Yang PC. (2011) Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy. PLoS One. 6:e23756.
  33. Tsai ZY, Chou CH, Lu CY, Singh S, Yu SL, Li SS. (2011) Proteomic comparison of human embryonic stem cells with their differentiated fibroblasts: Identification of 206 genes targeted by hES cell-specific microRNAs. Kaohsiung J Med Sci. 27:299-306.
  34. Yang YL, Hung CC, Chen JS, Lin KH, Jou ST, Hsiao CC, Sheen JM, Cheng CN, Wu KH, Lin SR, Yu SL, Chen HY, Lu MY, Wang SC, Chang HH, Lin SW, Su YN, Lin DT. (2011) IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: A multicenter analysis in Taiwan. Cancer Sci. 102:1874-1881
  35. Hsieh WY, Chou CC, Ho CC, Yu SL, Chen HY, Chou HY, Chen JJ, Chen HW, Yang PC. (2012) Single-Walled Carbon Nanotubes Induce Airway Hyper-Reactivity and Parenchymal Injury in Mice. Am J Respir Cell Mol Biol. 46(2):257-67
  36. Kang-Yi Su, Hsuan-Yu Chen, Ker-Chau Li, Min-Liang Kuo, James Chih-Hsin Yang, Wing-Kai Chan, Bing-Ching Ho, Gee-Chen Chang*, Jin-Yuan Shih*, Sung-Liang Yu*, and Pan-Chyr Yang. (2012) Pretreatment Epidermal Growth Factor Receptor (EGFR) T790M Mutation Predicts Shorter EGFR Tyrosine Kinase Inhibitor Response Duration in Patients With Non-Small-Cell Lung Cancer. Journal of Clinical Oncology. 2012 Feb 1;30(4):433-40. (*Corresponding Author, GC Chang, JY Shih and Yu SL equal contribution)
  37. Yang YL, Hsiao CC, Chen HY, Lin KH, Jou ST, Chen JS, Chang TK, Sheen JM, Yu SL, Lu MY, Cheng CN, Wu KH, Wang SC, Wang JD, Chang HH, Lin SR, Lin SW, Lin DT. (2012) Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer. Jun;58(6):846-51.
  38. Chen HY, Yu SL, Li KC, Yang PC. (2012) Biomarkers and Transcriptome Profiling of Lung Cancer. Respirology. 2012 May;17(4):620-6.
  39. Lai JH, She TF, Juang YM, Tsay YG, Huang AH, Yu SL, Chen JJ, Lai CC. (2012) Comparative proteomic profiling of human lung adenocarcinoma cells (CL 1-0) expressing miR-372. Electrophoresis. 2012 Feb;33(4):675-88
  40. Chung LY, Tang SJ, Sun GH, Chou TY, Yeh TS, Yu SL, Sun KH. (2012) Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2. Clin Cancer Res. 2012 Aug 1;18(15):4037-4047
  41. Chiu HC, Lee SL, Kapuriya N, Wang D, Chen YR, Yu SL, Kulp SK, Teng LJ, Chen CS. (2012) Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem. 2012 Aug 1;20(15):4653-60.
  42. Chen CH, Chuang SM, Yang MF, Liao JW, Yu SL, Chen JJ. (2012) A Novel Function of YWHAZ/β-Catenin Axis in Promoting Epithelial-Mesenchymal Transition and Lung Cancer Metastasis. Mol Cancer Res. 2012 Oct;10(10):1319-31.
  43. Yang YC, Lin HY, Su KY, Chen CH, Yu YL, Lin CC, Yu SL, Yan HY, Su KJ, Chen YL. (2012) Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evid Based Complement Alternat Med. 2012;2012:980276. Epub 2012 Aug 16.
  44. Ou JP, Lin HY, Su KY, Yu SL, Tseng IH, Chen CJ, Hsu HC, Chan DC, Sophia Chen YL. Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling. Evid Based Complement Alternat Med. 2012;2012:809204. doi: 10.1155/2012/809204. Epub 2012 Sep 24.
  45. Lai YH, Yu SL, Chen HY, Wang CC, Chen HW, Chen JJ. The HLJ1-targeting drug-screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer. Carcinogenesis. 2013 Jan 9. [Epub ahead of print]
專利
  1. 用微核醣核酸預測經治療之癌症患者存活率的方法 (美國, 2010/6/29, US Patent No. 7,745,134;臺灣, 2012/07/11, TW Patent No. I367949;新加坡, 2010/10/29, SG Patent No. 155730)
  2. 一種利用特定基因組合之表現特徵鑒定腫瘤組織及亞型,以及用以預測患者預後與轉移相關的方法(美國, 2011/4/21, Patent No. 11/437,607)
  3. 以微核醣核酸miR-141為標的治療小RNA病毒感染 (美國, 2010/6/29, US Patent No. 8,263,570;臺灣, 2012/07/11,)
  4. 基因拷貝數變異標記預測肺腺癌的預後與標靶治療的療效 (美國暫時性專利, US/61/504,512;臺灣專利申請中)
  5. 分枝桿菌的鑒定與抗藥性判定的快速篩檢方法 (美國暫時性專利, US/61/752102)