專任教師 English

 

俞松良老師

學歷

國立臺灣大學醫學院醫事技術學系 學士

國立臺灣大學醫學院醫事技術研究所 碩士

國立陽明大學微生物及免疫學研究所 博士

 

職稱

國立臺灣大學醫學檢驗暨生物技術學系
助理教授

國立臺灣大學附設醫院檢驗醫學部
兼任醫檢師

 

Email：slyu@ntu.edu.tw

 

電話：02-23123456轉88697

 

研究主題

基因體學

腫瘤醫學

微生物學

肺癌是最常見引起死亡的癌症。但是，目前臨床病理分期方法對肺癌治療預後的預測並不準確。因此，我們希望由基因層次探討癌生成與轉移的機制、發展癌症標記及預測肺癌病人的復發與存活率，最終找出癌症標記，並針對個別病人的狀況進行個人化醫療評估。微核醣核酸是一類新的小核醣核酸，其扮演負向性的基因調節功能，在腫瘤學研究中，微核醣核酸的表現剖繪與訊息核醣核酸皆可準確地進行癌症亞型分類。因此，我們針對肺癌病患的微核醣核酸表現進行研究，是否其表現可以用於預測肺癌病患治療後的存活率。該技術可應用於癌症分子病理學的研究或新標把性治療的開發，更可進一步發展成檢測用套組，以用於評估病患預後效果，並可有助於選擇高風險的癌症病人，在早期即進行輔佐性化療，或給予更進一步的治療。

 
代表著作
  1. Chen HW, Yu SL, Chen JJW, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, and Yang PC. (2004) Anti-Invasive Gene Expression Profile of Curcumin in Lung Adenocarcinoma Based on a High Throughput Microarray Analysis. Mol. Pharmacol. 65: 99-110.
  2. Chen, HW, Yu SL, Chen, WJ, Yang, PC, Tzeng, CR, Li, HN, Peck, K, Chen, JJW, Lee, YT. (2004). Profiling of Gene Expression Pattern during Postnatal Myocardial Development by cDNA Microarray. Heart 90:927-934. (equal contribution). (SCI). (Original article).
  3. Yu SL, Huei-Wen Chen, Pan-Chyr Yang, Konan Peck, Min-Hui Tsai, Jeremy J.W. Chen, and Fang-Yue Lin. (2004) Differential Gene Expression in Gram-negative and Gram-positive Sepsis. Am. J. Resp. Crit. Care Med. 169:1135-1143. (Sung-Liang Yu and Huei-Wen Chen: equal contribution)
  4. Huei-Wen Chen, Jeremy J.W. Chen, Yu SL, Han-Ni Li, Pan-Chyr Yang, Ching-Mao Su, Heng-Kien Au, Ching-Wen Chang, Li-Wei Chien, Chieh-Sheng Chen, and Chii-Ruey Tzeng (2005). Transcriptomic analysis during blastocyst hatching by cDNA microarrray. Human Reproduction 20:2492-2501 (SCI). (Original article).
  5. Chen WJ, Chen HW, Yu SL, et al. (2005). Gene Expression Profiles in Hypoxic Preconditioning using cDNA Microarray Analysis: Altered Expression of an Angiogenic Factor, CEACAM-1. Shock 24: 124-131 (SCI). (Original article).
  6. Wen-Chien Chou, Hsuan-Yu Chen, Yu SL, Linzhao Cheng, Pan-Chyr Yang, Chi V. Dang. (2005) Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood 106:304-310 (SCI). (Original article).
  7. Yu SL (2005) ABC’s of microarray微陣列概論. Formosan Journal of Medicine 9 (5):603-613.
  8. Huei-Wen Chen, Sheng-Fang Su, Chiang-Ting Chien, Wei-Hsiang Lin, Yu SL, Cheng-Chung Chou, Jeremy J.W. Chen, and Pan-Chyr Yang (2006) Titanium Dioxide Nanoparticles Induce Emphysema-like Lung Injury in Mice. FASEB J 20(13): 2393 – 2395 (SCI). (Original article).
  9. Sher Singh,Hsiu-Yi Ou Yang, Mei-Ying Chen, Yu SL* (2007) A Kinetic-Dynamic Model for Regulatory RNA Processing. Journal of Biotechnology 127:488-495 (SCI). (Original article, Corresponding Author).
  10. Hsuan-Yu Chen, Yu SL, Chun-Houh Chen, Gee-Chen Chang, Chih-Yi Chen, Ang Yuan, Chiou-Ling Cheng, Chien-Hsun Wang, Harn-Jing Terng, Shu-Fang Kao, Wing-Kai Chan, Han-Ni Li, Chun-Chi Liu, Sher Singh, Wei J. Chen, Jeremy J.W. Chen, Pan-Chyr Yang (2007) A 5-Gene Signature and Clinical Outcome of Non-small Cell Lung Cancer. N Engl J Med 356: 11-20 (SCI). (Original article).
  11. Yu SL, Chen HY, Yang PC*, and Chen JJW* (2007) Unique MicroRNA Signature and Clinical Outcome of Cancers. DNA and Cell Biology 26: 283-292 (SCI). (Review).
  12. Liu YL, Fann CS, Liu CM, Chang CC, Yang WC, Hung SI, Yu SL, Hwang TJ, Hsieh MH, Liu CC, Tsuang MM, Wu JY, Jou YS, Faraone SV, Tsuang MT, Chen WJ, Hwu HG. (2007) More evidence supports the association of PPP3CC with schizophrenia. Mol Psychiatry 12; 966-974 (SCI). (Original article).
  13. Yu SL, Hsuan-Yu Chen, Gee-Chen Chang, Chih-Yi Chen, Huei-Wen Chen, Sher Singh, Chiou-Ling Cheng, Chong-Jen Yu, Yung-Chie Lee, Han-Shiang Chen, Te-Jen Su, Ching-Cheng Chiang, Han-Ni Li, Qi-Sheng Hong, Hsin-Yuan Su, Chun-Chieh Chen, Wan-Jiun Chen, Chun-Chi Liu, Wing-Kai Chan, Wei J. Chen, Ker-Chau Li, Jeremy J.W. Chen, and Pan-Chyr Yang. (2008) MicroRNA Signature Predicts Survival and Relapse in Lung Cancer. Cancer cell 1; 48-57 (SCI). (Original article).
  14. Yu SL, Sher Singh, PhD, Huei-Wen Chen, Hsuan-Yu Chen, Jeremy J.W. Chen, PhD, Wen-Jone Chen, Han-Shiang Chen, Shyr-Chyr Chen. (2008) Intra-abdominal Adhesion Formation Induces Anti-oxidative Injury, Enhances Cell Proliferation, and Prevents Complement-mediated Lysis. Wound Repair and Regeneration (16(3):388-98.) (SCI). (Original article).
  15. Chen HW, Jen-Yi Lee, Ji-Ying Huang, Chi-Chung Wang , Wan-Jiun Chen, Sheng-Fang Su, Chia-Wen Huang, Chao-Chi Ho, Meng-Feng Tsai, Sung-Liang Yu, Jeremy JW Chen, and Pan-Chyr Yang (2008) Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1 Cancer Research 68; 7428-38. (SCI). (Original article).
  16. Yu-Chih Chao, Szu-Hua Pan, Shuenn-Chen Yang, Sung-Liang Yu, Che-Hsiang Wu, Chung-Wu Lin, Mu-shiun Tsai, Gee-Chen Chang, Ting-Fang Che, Yi-Ying Wu, Tse-Ming Hong, and Pan-Chyr Yang. (2009) Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma. Am. J. Respir. Crit. Care Med. 179; 123-33. (SCI). (Original article).
  17. Wan-Hsin Liu, Shiou-Hwei Yeh, Cho-Chun Lu, Sung-Liang Yu, Hsuan-Yu Chen, Chien-Yu Lin, Ding-Shinn Chen and Pei-Jer Chen. (2009) Elevation of MicroRNA-18a Downregulates Estrogen Receptor Alpha and Stimulates Hepatocyte Proliferation in Female Hepatocellular Carcinoma. Gastroenterology. 136; 683-93. (SCI). (Original article).
  18. Steven Shoei-Lung Li, Sung-Liang Yu, Li-Pin Kao, Zong Yun Tsai, Sher Singh, Bo Zhi Chen, Bing-Ching Ho, Yung-Hsien Liu and Pan-Chyr Yang. (2009) Target identification of microRNAs expressed highly in human embryonic stem cells. Journal of Cellular Biochemistry. 106; 1020-30. (SCI). (Original article).
  19. Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. (2009) Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-kappaB Pathways. J Med Chem. Mar 13. [Epub ahead of print] (SCI). (Original article).
  20. Kao LP, Yu SL, Singh S, Wang KH, Kao AP, and Li SSL. 2009. Comparative Profiling of mRNA and microRNA Expression in Human Mesenchymal Stem Cells Derived from Adult Adipose and Lipoma Tissues. The Open Stem Cell Journal. 1(9):1-9. (equal contribution) (Original article).
  21. Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, Wang DS, Lu YS, Hsu C, Cheng AL. 2009. Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res. 15:5820-8.
  22. Zong-Yun Tsai, Sher Singh, Sung-Liang Yu, Li-Pin Kao, Bo-Zhi Chen, Bing-Ching Ho, Pan-Chyr Yang and Steven Shoei-Lung Li. (2009) Identification of microRNAs regulated by activin A in human embryonic stem cells. Journal of Cellular Biochemistry. (In Press)