林淑萍老師

學歷

臺大農化系 學士
臺大農化研究所 碩士
美國 約翰霍普金斯大學 生物化學 博士

職稱

臺大醫事檢驗暨生物技術學系 教授
臺大醫學院附設醫院檢驗醫學部 研究員
臺大應用力學研究所 合聘教授

學會

台灣醫事檢驗學會
中華民國臨床生化學會
臺灣蛋白體學會

Email：sblin@ntu.edu.tw

電話：02-23123456轉66910或 66923

老師的話

趁年輕多方體驗，發掘志趣所在；從生活累積智慧，凡事盡己所能；其餘的交給上帝。

嗜好

閱讀、旅遊、音樂

研究主題

一、天然物小分子活性的研究
二、以蛋白體學技術研發檢驗標記
三、肝纖維化微血檢測儀開發

一、天然物小分子活性的研究
　　自各種植物純化具生化活性的小分子化合物並研究它們的作用機轉。自天然漆樹汁液萃取之氫醌化合物，研發其醫藥組成物及製法已獲專利；研究並發現其所含的氫醌化合物的抗癌活性、化學保健以及皮膚美白的功效，發表於國際知名期刊。自靈芝純化出許多三萜類，發現靈芝三萜具有抗癌活性，研究抗癌活性機轉有多篇論文發表；並與業界合作研究開發以科學方法證明靈芝的傳統功效。尚有多個活性小分子化合物的研究在進行中。本研究目的在加強傳統中草藥的科學基礎，提昇傳統中草藥的科學地位。

二、以蛋白體學技術研發檢驗標記
　　以新穎研究蛋白體學(proteomics)的技術研發檢驗標誌，利用以高壓層析串聯質譜(LC-MS/MS)為主的分析技術研究血清蛋白體，以發現血液中疾病的檢驗標記。目前已經針對肝纖維化，發現數個新穎肝纖維化的血液檢驗標記，正在申請專利；而且這些肝纖維化的標記將使用在肝纖維化微血檢測儀的開發。

三、開發肝纖維化生物標記診斷套組暨微血檢測儀
　　肝纖維化為肝臟因病毒性肝炎、酗酒、藥物等等原因而導致肝內出現纖維化組織的慢性疾病，之後整個肝臟變硬，也常發展成肝癌。肝硬化在初期症狀不明顯，且單一肝功能指數檢驗不足以診斷病情。以肝穿刺法來診斷肝纖維化是目前的標準方法，一般人對這種高侵襲性的檢驗接受性低，常因延宕錯失治療良機。若能以抽血檢驗診斷肝硬化，這種侵襲性較低的檢驗方法將有助於肝硬化的早期發現早期治療。有鑑於此，我們與臺大應力所、臺大醫工所、臺大臨床醫學研究所、工研院醫材中心及百奧生物科技公司合作共同進行「肝纖維化/肝硬化生物標記診斷套組暨肝纖維化微血檢測儀開發」之整合型計畫。

期刊論文

1. Wu YT. Jiaang WT, Lin KG, Huang CM. Chang CH, Sun YL, Fan KH, Hsu WC, Wang HE, Lin SB, Chen ST. A new N-acetylgalactosamine containing peptide as a targeting vehicle for mammalian hepatocytes via asialoglycoprotein receptor endocytosis. Current Drug Delivery 2004; 1:119-127.
2. Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS, Lin SB*, Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis in cancer cells. Life Sci. 2005; 77:256-265 (SCI)
3. Chang UM, Li CH, Lin LI, Huang CP, Lin SB*, Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Life Sci. 2006, 79:1129-39 (SCI)
4. Wang WB, Lai HC, Hsueh PR, Chiou RY, Lin SB, Liaw SJ. Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol. J Med Microbiol. 2006; 55:1313-21. (SCI)
5. Ou DL, Chen CL, Lin SB, Hsu CH, Lin LI, Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapy. J Pathol. 2006; 210: 363-73 (SCI)
6. Lin SB, Kolippakkam D, Lai MY, Chen DS, Beretta L. Glycopeptide profiling as a tool to discover novel markers of disease progression in liver fibrosis. Mol Cell Proteomics. 2006; 5(10): S263. (SCI)
7. Chen GS, Bhagwat BV, Liao PY, Chen HT, Lin SB, Chern JW. Specific stabilization of DNA triple helices by indolo[2,1-]quinazolin-6,12-dione derivatives. Bioorg Med Chem Lett. 2007;17:1769-72. (SCI)
8. Liu YT, Lin SB, Huang CP, Huang CM. A novel immunogenic spore coat-associated protein in Bacillus anthracis: Characterization via proteomics approaches and a vector-based vaccine system. Protein Expr Purif. 2008;57: 72-80. (SCI)
9. Huang CP, Fang WH, Lin LI, Chiou RY, Kan LS, Chi NH, Chen YR, Lin TY, Lin SB*. Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning. Toxicol. Appl. Pharmacol. 2008;227:301-8 (SCI)
10. Huang CP, Liu YT, Nakatsuji T, Shi Y, Gallo R, Lin SB*, Huang CM*. Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes. Proteomics - Clinical Applications. 2008; 2:1234 -45. (SCI)
11. Chen YR, Chiou RY, Lin TY, Huang CP, Tang WC, Chen ST, Lin SB*. Identification of an alkylhydroquinone from Rhus succedanea as an inhibitor of tyrosinase and melanogenesis. J Agric Food Chem. 2009;57:2200-5. (SCI)

研發成果智慧財產權

自天然漆樹(Rhus succedanea)汁液萃取之氫醌化合物,其醫藥組成物及製法。中華民國專利 I-237632，專利期間: 2005/08/00 ~ 2022/05/00

研討會論文摘要

Chung PC, Chiou RYY, Huang CP, Lin SB* Arachin-1, a peanut stilbenoid, induced apoptosis in HL-60 cells by activating both caspase-dependent and caspase –independent pathway. 第24屆生物醫學聯合學術年會. 2009/03/21~22, Abstract #P86

Lin, TY, Huang CP, Chen YR, Lin SB*. Chemopreventive effects of HQ17(3), a natural occurring antioxidant, involves activation of cellular anti-oxidative signaling pathway. 第24屆生物醫學聯合學術年會. 2009/03/21~22, Abstract #P85.

Huang CP, Chiou SW, Lin SB*. SCA-1+ and CD44+ cancer stem-like cells in Lewis lung cancer cell line (臺灣幹細胞年會 2008, 臺北)

HQ17(1), a Tyrosinase Inhibitor with Effective Skin Whitening Potency Extracted from Rhus Succedanea 第23屆生物醫學聯合學術年會. 2008/3/29~30

Huang CP, Chiou RYY, Chen YR, Lin TY, Lin SB*. Botanical alkylhydroquinone induced apoptosis in hepatoma cancer cells. 第23屆生物醫學聯合學術年會. 2008/3/29~30. 獲優秀壁報論文獎

Facilitating the detection of protein immunogenicity: a platform integrating proteomics, vector-based vaccines and antigen microarrays. Biotechnology Taiwan, 2007, Taipei, 2007/09/28~30

Tang WC, Lin TY, Lai MY, Lin SB*. Discovery of liver fibrosis biomarkers by analysis of serum N-glycoproteome. Human Proteomic Organization 6th World Annual Congress, Korea. 2007/10/06~10.

Chen YR, Shui HA, Chen ST, Lin SB*. Increased expression of α-enolase in rat liver epithelial tumor cells, GP7TB, detected by 2D gel electrophoresis and MALDI-TOF. Human Proteomic Organization 6th World Annual Congress, Korea. 2007/10/06~10.

Lin, Shwu-Bin.. Serum N-glycoprotein Biomarker Candidates for Detecting Hepatitis C Virus Related Liver Fibrosis. Taiwan Proteomics Society International Conference. 2007/12/04-05,

Lin, Shwu-Bin.. N-Glycoproteome Profiling for Development of Liver Fibrosis Markers. Annual Symposium of Hong Kong Proteomics Society and Satellite Meeting of CNHUPO. 2007/08//23~25.

Tang WC, Lin TY, Lai MY, Chen DS, Beretta L, Lin SB*. N-glycoproteome profiling by nanoLC-MS/MS peptide analysis for biomarker discovery. American Association for Clinical Chemistry 39th Annual Oak Ridge Conference. 2007/04//19~20. 

Lin, Shwu-Bin. Anticancer activity of Ganoderma triterpenes. Symposium on Phytochemicals and Applied Microbiology. 2007/06/27.

Tang WC, Lin TY, Lai MY, Chen DS, Lin SB*. Discovery of disease marker by direct LC-MS/MS peptide analysis to profile serum N-glycoproteomes of patients and normal controls. 55th American Society of Mass Spectrometry Conference, 2007/06/03~07.

Tang WC, Lin TY, Lai MY, Chen DS, Beretta L, Lin SB*. Discovery of liver fibrosis biomarkers by analysis of serum N-glycoproteome. 第22屆生物醫學聯合學術年會. 2007/03/24~25. 獲優秀壁報論文獎

Lin SB, Kolippakkam D, Lai MY, Chen DS, Beretta L. Glycopeptide profiling as a tool to discover novel markers of disease progression in liver fibrosis. Human Proteome Organization 5th Annual World Congress, Long Beach. 2006/10/28~11/01

Lin, Shwu-Bin. Discovery of Serum Biomarker of Hepatic Fibrosis in HCV Infected Patients. International Cancer Biomarker Consortium Workshop. Korea Research Institute of Bioscience and Biotechnology. 2006/09/17~19.

Huang CP, Chiou RY, Chi, NH, Tang WC, Chen YJ, Huang CJ, Lin SB*. Hepta- decatrientrienylhydroquinone depletes sulfhydryl contents, inhibits topoisomerase II and induces apoptosis in cancer cells. 第20屆生物醫學聯合學術年會., Taipei, Taiwan. 2005/03/ 26~27

Huang YC, Chao YC, Lin SB, Tsai HK, Chang CF, Kao CY. A Tool to Determine the Specificity of Antisense Oligonucleotide. International Multi-Conference in Computer Science & Computer Engineering. Las Vegas, Nevada, USA. 2004/06/21-24.

Huang CP, Chiou RY, Fang WH, Lin SB* (2004) Inhibitory effects of a novel alkylated hydroquinone on DNA topoisomerase II. 第19屆生物醫學聯合學術年會. Taipei, Taiwan, Page 237.