專任教師 English

     
    林亮音老師
  學歷
 

台大醫事技術學系 理學士
台大醫學院生化所 碩士
台大醫學院生化所 博士
   
  職稱
 

台大醫學院醫學檢驗暨生物技術學系 教授
台大醫院檢驗醫學部分子檢驗科 主任
台大醫院檢驗醫學部/內科部 兼任研究員醫檢師
   
  Email：lilin@ntu.edu.tw
   
  電話：02-23123456轉66913或67342
   
  代表著作
Original articles-selected:
(1)
Yu CY, Chen J, Lin LI, Tam M and Shen CKJ: Cell type-specific protein-DNA interactions in the human ζ-globin upstream promoter region: displacement of Sp1 by the erythroid cell-specific factor NF-E1. Mol cell Biol 10: 282-294, 1990.
   
(2)
Lin LI, Lin KS, Lin KH and Chang HC: The spectrum of β-thalassemia mutations in Taiwan: identification of a novel frameshift mutation. Am J Hum Genet 48: 809-812, 1991.
   
(3)
Lin LI, Lin KS and Lin DT: Analysis of hemoglobin gamma chain in patients with Cooley’s anemia in Taiwan. J Formosan Med Assoc 91: 121-125, 1992.
   
(4)
Lin LI, Liu CH, Chen YC, Shen MC, Wang CH, Huang YL and Lin JK: PIG-A gene mutations in four Taiwanese patients with paroxysmal nocturnal hemoglobinuria following aplastic anemia. Br J Haematol 97: 286-292, 1997.
   
(5)
Lin LI, Ke YF, Ko YC, Lin JK. Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion. Oncology 55:349-353, 1998.
   
(6)
Wei CC, Chiang FT, Lin KS, Lin LI*(correspondent). The spectrum of microsatellite loci on chromosome 7 and 8 in Taiwan aboriginal populations – a comparative population genetic study. Hum Genet 104: 333-340, 1999.
   
(7)
Lin LI, Lin DT, Chang CJ, Lee CY, Tang JL, Tien HF: Marrow matrix metalloproteinases (MMPs) and tissue inhibitors of MMP in acute leukaemia: potential role of MMP-9 as a surrogate marker to monitor leukaemic status in patients with acute myelogenous leukaemia. Br J Haematol, 117: 835-841, 2002.
   
(8)
Kuo SH, Lin LI, Chang CJ, Liu YR, Lin KS, Cheng AL: Increased risk of parvovirus B19 infection in young adult cancer patients receiving multiple courses of chemotherapy. J Clin Microbiol, 40: 3909-3912, 2002.
   
(9)
Lin LI, Chen CY, Lin DT, Tsay W, Tang JL, Yeh YC, Shen HL, Su FH, Yao M, Huang SY, Tien HF. Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. Clin Cancer Res 11: 1372-1379, 2005.
   
(10)
Chou WC, Tang JL, Lin LI, Yao M, Tsay W, Chen CY, Wu SJ, Huang CF, Chiou RJ, Tseng MH, Lin DT, Lin KH, Chen YC, Tien HF. Nucleophosmin Mutations in de novo Acute Myeloid Leukemia: Age-Dependent Incidences and The Stability During Disease Evolution. Cancer Res, 66: 3310-3316, 2006.
   
(11)
Chen CY, Lin LI, Tang JL, Tsay W, Chang HH, Yeh YC, Huang CF, Chiou RJ, Yao M, Ko BS, Chen YC, Lin KH, Lin DT, Tien HF Acquisition of JAK2, PTPN11, and RAS Mutations during Disease Progression in Primary Myelodysplastic Syndrome. Leukemia, 20: 1155-1158, 2006.
   
(12)
Ou DL, Chen CL, Lin SB, Hsu CH, Lin LI* (correspondent). Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapy. Journal of Pathology, 210: 363-373, 2006.
   
(13)
Lin LI, Lin TC, Chou WC, Tang JL, Lin DT, Tien HF. A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias. Leukemia, 20: 1899-1903, 2006.
   
(14)
Lee CY, Tien HF, Hu CY, Chou WC, Lin LI* (correspondent). Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia. Br J Cancer, 97: 877-882, 2007.
   
(15)
Chen CY, Lin LI, Tang JL, Ko BS, Tsay W, Chou WC, Yao M, Wu SJ, Tseng MH, Tien HF. RUNX1 gene mutation in primary myelodysplastic syndrome - the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome. Br J Haematol, 139: 405-414, 2007.
   
(16)
Hou HA, Chou WC, Lin LI, Tang JL, Tseng MH, Huang CF, Yao M, Chen CY, Tsay W, Tien HF. Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia. Leuk Res 32: 904-912, 2008.
   
(17)
Hou HA, Chou WC, Lin LI, Chen CY, Tang JL, Tseng MH, Huang CF, Chiou RJ, Lee FY, Liu MC, Tien HF. Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. Leukemia 22: 1075–1078, 2008.
   
(18)
Lee CY, Tien HF, Hou HA, Chou WC, Lin LI *(correspondent). Marrow osteopontin level as a prognostic factor in acute myelogenous leukemia. Br J Haematol 141: 736–739, 2008.
   
(19)
Huang CP, Fang WH, Lin LI, Chiou RY, Kan LS, Chi NH, Chen YR, Lin TY, Lin SB. Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning. Toxicol Appl Pharmacol 227: 331-338 2008.
   
(20)
Ou DL, Chien HF, Chen CL, Lin TC, Lin LI* : Role of Twist in head and neck cancer with lymph node metastasis. Anticancer Res 28: 1355-1360 2008.

 
(21)
Chou WC, Chen CY, Hou HA, Lin LI*, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Tseng MH, Huang CF, Tien HF.Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia 23: 1303-1310, 2009.

 
(22)
Hou HA, Lin LI, Chen CY, Tien HF. Reply to ‘Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favorable prognosis.Br J Cancer 101: 738-740, 2009.

 
(23)
Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH, Huang CF, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Lin LI*, Tien HF* (Co-correspondent). AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood 2009 Oct 6. [Epub ahead of print]

 
Meeting abstracts
(1)
Lin LI, Lin DT, Tang JL, Liu PL, Tien HF: Distinctive mechanisms of impaired CXCR4/SDF chemotaxis in acute leukemia. Blood 102: 236b, 2003
   
(2)
Lin LI, Chen HC, Tang JL, Li DK, Wang CH, Tien HF: Methylation status of the DAPK gene in myelodysplastic syndrome – a high frequency of the gene methylation in chronic myelomonocytic leukemia. Blood 102: 328b, 2003
   
(3)
Lin LI, Lee CY, Lin DT, Wen HW, Tien HF: Clinical Application of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 Expression in Patients with CML. Blood 104: 35b, 2004.
   
(4)
Lin LI, Lee CY, Hu CY, Tang JL, Tien HF: Significance of marrow angiogenesis factors in patients with acute myelogenous leukemia. Blood 108: 184b, 2006.
   
(5)
Lin TC, Lee CY, Tien HF, Hu CY, Tang JL, Lin LI: Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in acute myeloid leukemia. Blood 110: 629a-630a, 2007.