Clinical Biochemistry: Genetic study of Chinese hypertriglyceridemia. Using antisense oligonucleotides as probes to detect cancer cells and as anticancer agents. Investigating the correlation between DNA repair and certain genetic disease by in vitro assays.

Clinical hematology presently emphasizes research in hematological diseases. Genetic disorders are under intensive investigation including thalassemia syndrome involving globin gene abnormality, the molecular mechanisms of paroxysmal nocturnal hemoglobinuria, and aplastic anemia. Study the molecular defects of hemophilia A and B, assessing the carrier status and prenatal diagnosis for those families. Study factors VII, VIII, IX and X by protein engineering using site-directed mutagenesis. Developing transgenic mice technology and used the technique in fields of hematology and cancer.

Clinical Bacteriology: Application of gas chromatography and mass spectrometry in rapid detection of bacterial and fungal metabolites and cellular fatty acids. Using molecular methods to detect antimicrobial resistance genes and to study mechanisms of drug resistance. Develop of molecular epidemiology such as chromosome fragment fingerprinting or ribotyping for epidemiological study. Detect slow-growing bacteria by using PCR technology. Study the bacterial virulence factors and gene regulation. Mechanism of bacterial cell differentiation and population migration and the regulation of cell-differentiation associated genes.

Clinical Virology: Development and application of laboratory methods in rapid diagnosis of viral infections. Study Molecular Epidemiological of virus infections in Taiwan. Study mechanism of anti-viral drug resistance. Developing viral vaccines and diagnostic reagents. Study the prognostic markers for HIV-I disease progression.

Clinical Serology and Immunology: Improvement and application of immunoassays.

Research in Serology of human tissue types for the application of organ transplantation and disease association. Research HLA DNA typing for the application of anthropology, paternity identification and disease association. Developing an fast method of molecular technique of DNA tissue typing for clinical laboratory tests.

Study on the tumor necrosis factor –α triggered apoptosis on human T cells and the susceptibility of HTLV-I-infected T cells to TNF-α-induced apoptosis. Study molecular genetics of inherited colorectal cancer, FAP and HNPCC.