聯絡資訊

地址：台北市仁愛路一段一號 臺大醫學院 解剖暨細胞生物學科 638室

E-Mail: shsieh@ntu.edu.tw

經歷

學歷：

  • 台灣大學 醫學士
  • 美國哈佛大學 公共衛生碩士
  • 美國約翰霍普金斯大學 神經科學博士

現職：

  • 國立台灣大學 解剖學暨細胞生物學研究所 教授
  • 台大醫院 神經部 主治醫師

研究領域

周邊神經的神經生物學

  • 神經痛
  • 神經退化與再生

職司冷、熱、痛的感覺，對於生物體的保護極為重要，負責傳送這些感覺訊息的神經通常直徑極微 (僅有一至數微米) ，稱為無髓鞘 (unmyelinated) 或小直徑有髓鞘 (small myelinated) 神經纖維，這些神經如果退化，則個體容易因為不能辨識冷、熱的剌激而受傷 (painless injury) 。因為這些神經的直徑極小，過去的研究必須仰賴電子顯微鏡，電子顯微鏡對於超微結構的觀察、分析極為重要，然其步驟繁複，且能觀察之區域有限，對於研究神經軸突退化的現象有其所限制。為能在一般光學顯微鏡下，有系統的評估這些小直徑神經纖維的退化與再生，本實驗室在過去數年利用各種研究方法，包括免疫化學染色 (Immunocytochemistry) ，電子顯微鏡觀察，生化技術 (如聚合酵素鏈反應, polymerase chain reaction, PCR) ，致力於建立周邊神經病變之實驗模式，以了解神經退化與再生之機轉。

周邊神經病變

  • 遺傳型神經病變：基因診斷
  • 免疫型神經病變

負責計畫

  • 國科會：糖尿病神經病變
  • 國衛院：疼痛型感覺神經病變
  • 工研院：神經再生導管動物試驗

研究 教學成果

獎勵

  • 1995 美國 實驗神經病理學會 (Society for Experimental Neuropathology)：Peter Lampert Young Investigator Award
  • 1997 台大醫學院 優良教學獎
  • 2000 台大醫學院 青杏醫學研究獎
  • 2001 陳萬裕教授基金會 醫學研究獎
  • 2002 北美校友基金會 最佳教師獎
  • 2003 台灣大學 教學傑出獎
  • 2003 國科會 傑出研究獎
  • 2005 台灣神經醫學會 默沙東最佳論文獎
  • 2008 國科會 傑出學者研究計畫
  • 2008 台灣大學 教學傑出獎
  • 2009 國科會 傑出研究獎

期刊論文    search Pubmed

  1. Tseng MT, Tseng WY, Chao CC, Lin HE, Hsieh ST. Distinct and shared cerebral activations in processing innocuous versus noxious contact heat revealed by functional magnetic resonance imaging. Hum Brain Mapp 2010; 31:743-757.
  2. Hsieh YL, Lin WM, Lue JH, Chang MF, Hsieh ST. Effects of 4-methylcatechol on skin reinnervation: promotion of cutaneous nerve regeneration after crushing injury.J Neuropathol Exp Neurol 2009; 68:1269-1281.
  3. Chao CC, Hsieh SC, Tseng MT, Chang YC, Hsieh ST. Patterns of contact heat evoked potential (CHEP) in neuropathy with skin denervation: correlation of CHEP amplitude with intraepidermal nerve fiber density. Clin Neurophysiol 2008; 119:653-661.
  4. Chao CC, Sun HY, Chang YC, Hsieh ST. Painful neuropathy with skin denervation after prolonged use of linezolid.J Neurol Neurosurg Psychiatry 2008; 79:97-99.
  5. Hsieh YL, Chiang H, Tseng TJ, Hsieh ST. Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.J Neuropathol Exp Neurol 2008; 67:93-104.
  6. Lin YY, Tseng TJ, Hsieh YL, Luo KR, Lin WM, Chiang H, Hsieh ST. Depletion of peptidergic innervation in the gastric mucosa of streptozotocin-induced diabetic rats.Exp Neurol 2008; 213:388-396.
  7. Tseng TJ, Chen CC, Hsieh YL, Hsieh ST. Influences of surgical decompression on the dorsal horn after chronic constriction injury: Changes in peptidergic and d-opioid receptor (+) nerve terminals.Neuroscience 2008; 156:758-768 .
  8. Chao CC, Hsieh ST, Chiu MJ, Tseng MT, Chang YC. Effects of aging on contact heat evoked potentials: the physiological assessment of thermal perception.Muscle Nerve 2007; 36:30-38..
  9. Tseng TJ, Chen CC, Hsieh YL, Hsieh ST. Effects of decompression on neuropathic pain behaviors and skin reinnervation in chronic constriction injury.Exp Neurol 2007; 204:574-582.
  10. Chao CC, Hsieh ST, Shun CT, Hsieh SC. Skin denervation and cutaneous vasculitis in eosinophilia-associated neuropathy.Arch Neurol 2007; 64:959-965.
  11. Chao CC, Hsieh SC, Yang WS, Lin YH, Lin WM, Tai TY, Hsieh ST. Glycemic control is related to the severity of impaired thermal sensations in type 2 diabetes.Diabetes Metab Res Rev 2007; 23:612-620.
  12. Lin CY, Su YN, Lee CN, Hung CC, Cheng WF, Lin WL, Chen CA, Hsieh ST. A rapid and reliable detection system for the analysis of PMP22 gene dosage by MP/DHPLC assay. J Hum Genet 2006; 51:227-235.
  13. Tseng MT, Hsieh SC, Shun CT, Lee KL, Pan CL, Lin WM, Lin YH, Yu CL, Hsieh ST. Skin denervation and cutaneous vasculitis in systemic lupus erythematosus. Brain 2006; 129:977-985.
  14. Lin CY, Su YN, Lee CN, Hung CC, Cheng WF, Lin WL, Chen CA, Hsieh ST. A rapid and reliable detection system for the analysis of PMP22 gene dosage by MP/DHPLC assay. J Hum Genet 2006; 51:227-235.
  15. Chiang HY, Chien HF, Shen HH, Yang JD, Chen YH, Chen JH, Hsieh ST. Reinnervation of muscular targets by nerve regeneration through guidance conduits. J Neuropathol Exp Neurol 2005; 64:576-587.
  16. Chiang HY, Chen CT, Chien HF, Hsieh ST. Skin denervation, neuropathology, and neuropathic pain in a laser-induced focal neuropathy. Neurobiol Dis 2005; 18:40-53.
  17. Lee JE, Shun CT, Hsieh SC, Hsieh ST. Skin denervation in vasculitic neuropathy. Arch Neurol 2005; 62:1570-1573.
  18. Lin YH, Hsieh SC, Chao CC, Chang YC, Hsieh ST. Influence of aging on thermal and vibratory thresholds of quantitative sensory testing. J Peripher Nerv Syst 2005; 10:269-281.
  19. Chang YC, Lin WM, Hsieh ST. Effects of aging on human skin innervation. NeuroReport 2004; 15:149-153.
  20. Hsieh ST, Chu NS. Immunohistochemical study of skin nerve regeneration after toe-to-finger transplantation: correlations with clinical, quantitative sensory, and electrophysiological evaluations. Acta Neurol Taiwan 2004; 13:178-185.
  21. Hsu SH, Lee MJ, Hsieh SC, Scaravilli F, Hsieh ST. Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4) gene. Neurobiol Dis 2004; 16:335-345.
  22. Pan CL, Kuo MF, Hsieh ST. Auditory agnosia caused by a tectal germinoma. Neurol 2004; 63:2387-2389.
  23. Pan CL, Shun CT, Susuki K, Yuki K, Hsieh ST. Pharyngeal-brachial palsy after cytomegalovirus colitis. Neurol 2004; 62:153-154.
  24. Shun CT, Chang YC, Wu HP, Hsieh SC, Lin WM, Lin YH, Tai TY, Hsieh ST. Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004; 127:1593-1605.
  25. Tsai LK, Hsieh ST, Chao CC, Chen YC, Lin YH, Chang SC, Chang YC. Neuromuscular disorders in severe acute respiratory syndrome. Arch Neurol 2004; 61:1669-1673.
  26. Chao CC, Tsai LK, Chiou YH, Tseng MT, Hsieh ST, Chang SC, Chang YC. Peripheral nerve disease in SARS: report of a case. Neurol 2003; 61:1820-1821.
  27. Pan CL, Tseng TJ, Lin YH, Chiang MC, Lin WM, Hsieh ST. Cutaneous innervation in Guillain-Barre syndrome: pathology and clinical correlations. Brain 2003; 126:386-397.
  28. Chiang MC, Lin YH, Pan CL, Tseng TJ, Lin WM, Hsieh ST. Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. Neurol 2002; 59:1094-1098.
  29. Ko MH, Chen WP, Hsieh ST. Neuropathology of skin denervation in acrylamide-induced neuropathy. Neurobiol Dis 2002; 11:155-165.
  30. Lyu RK, Chen WH, Hsieh ST. Plasma exchange versus double filtration plasmapheresis in the treatment of Guillain-Barre syndrome. Ther Apher 2002; 6:163-166.
  31. Chien HF, Tseng TJ, Lin WM, Yang CC, Chang YC, Chen RC, Hsieh ST. Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta Neuropathol (Berl) 2001; 102:455-461.
  32. Hsieh ST. Skin Biopsy: A New Window on Small-fiber Sensory Neuropathy. Acta Neurol Taiwan 2001; 10:1-8.
  33. Lin YW, Tseng TJ, Lin WM, Hsieh ST. Cutaneous nerve terminal degeneration in painful mononeuropathy. Exp Neurol 2001; 170:290-296.
  34. Pan CL, Yuki N, Koga M, Chiang MC, Hsieh ST. Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody. Neurol 2001; 57:1316-1318.
  35. Pan CL, Lin YH, Lin WM, Tai TY, Hsieh ST. Degeneration of nociceptive nerve terminals in human peripheral neuropathy. NeuroReport 2001; 12:787-792.
  36. Hsieh ST, Chiang HY, Lin WM. Pathology of nerve terminal degeneration in the skin. J Neuropathol Exp Neurol 2000; 59:297-307.
  37. Hsieh ST, Lin WM. Modulation of keratinocyte proliferation by skin innervation. J Invest Dermatol 1999; 113:579-586.
  38. Ko MH, Chen WP, Lin-Shiau SY, Hsieh ST. Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function. Exp Neurol 1999; 158:37-46.
  39. Lin WM, Hsieh ST, Huang IT, Griffin JW, Chen WP. Ultrastructural localization and regulation of protein gene product 9.5. NeuroReport 1997; 8:2999-3004.
  40. Hsieh ST, Choi S, Lin WM, Chang YC, McArthur JC, Griffin JW. Epidermal denervation and its effects on keratinocytes and Langerhans cells. J Neurocytol 1996; 25:513-524.
  41. McCarthy B, Hsieh ST, Stocks EA, Hauer P, Macko C, Cornblath DR, Griffin JW, McArthur JC. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurol 1995; 45:1848-1855.
  42. Hsieh ST, Kidd GJ, Crawford TO, Xu Z, Lin WM, Trapp BD, Cleveland DW, Griffin JW. Regional modulation of neurofilament organization by myelination in normal axons. J Neurosci 1994; 14:6392-6401.

大體解剖學

Skeletal system

Muscular system

Nedrvous system

大體實習相關資訊

神經解剖學

神經解剖圖譜

神經解剖學名詞

CNS overview

CNS overview (black-white version)

Limbic system

Limbic system (black-white version)

Blood vessels of CNS

Blood vessels of CNS (black-white version)

周邊神經教學

講義：周邊神經病變

周邊神經教學資料

總論

診斷

治療

分論

細胞生物學導論

Protein sorting and endocytotic pathway

Neuronal degeneration and regeneration

胚胎學

Development of musculoskeletal system

Development of musculoskeletal system (black-white version)

Development of nervous system

Development of nervous system (black-white version)

組織學

PNS

Cardiovascular system

CNS

Integumentary System

Eye and Ear

Salivary gland, Esophagus, and Stomach

醫藥保健資訊

周邊神經病變簡介

類澱粉神經病變

罕見疾病：類澱粉神經病變

台大醫院神經部：周邊神經病變

台大醫院神經部：神經肌肉疾病之診斷與治療