Attending Neurologist, Department of Neurology,
Department of Anatomy and Cell Biology,
Department of Anatomy and Cell Biology, RM#638, National Taiwan University College of Medicine, 1 Jen-Ai Road, Sec. 1, Taipei, 100, Taiwan
E-mail: shsieh@ ntu.edu.tw
PhD (Neuroscience), The
Master of Public Health (MPH, Environmental Health
MD, Department of Medicine,
Professor, Department of
Anatomy and Cell Biology,
Attending physician (Neurologist), Department of
Fellow, Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
2009 Outstanding Research Award, National
Science Council, Executive
Distinguished Scholars Research Project, National Science Council,
2008 Outstanding Teaching Award,
2005 Merck Sharp &
2003 Outstanding Teaching Award,
2003 Outstanding Research Award, National
Science Council, Executive
2002 Teaching Award, The Foundation of Alumni,
2001 Medical Research Award, Professor W. Chen
2000 Research Award,
1997 Teaching Award,
1995 Peter Lampert
Young Investigator Award, Society of Experimental Neuropathology,
Contact heat evoked potential
Neurobiology of nerve degeneration and its consequences of neuropathic pain (peripheral and central mechanisms)
Skin biopsy to diagnose human neuropathy affecting small-diameter nociceptive nerves (small-fiber neuropathy, painful neuropathy)
Plasticity in neural circuitry of neuropathic pain
Peripheral mechanisms: peripheral sensitization after nerve injury
Central mechanisms of neuropathic pain: changes in somatosensory pathways on functional magnetic resonance imaging (fMRI) and contact heat evoked potential (CHEP)
Diagnosis and therapy of peripheral neuropathy
Hereditary neuropathies: Characot-Marie-tooth disease (CMT), hereditary neuropathy with liability to pressure palsies (HNPP), familial amyloid polyneuropathy (FAP)
Inflammatory neuropathies: Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), Miller Fishere syndrome (MFS), neuropathies with anti-ganglioside antibodies
Our laboratory is devoted to investigate the neurobiological aspects of nerve degeneration and its consequences of neuroapthic pain, particularly focusing on small myelinated and unmyelinated nociceptive nerves (small-fibers) and their central pathways. These nerve fibers terminate in the skin and are responsible for the transmission of thermal and nociceptive stimuli. Previous studies were limited by their small diameter (usually 1-2 micrometers), and usually required electron microscopic examinations. We have developed new techniques to investigate the nerve terminals in a global scale, and used these approaches to set up models of nerve terminal degeneration. In addition to the loss of sensations, the other major consequence of nerve injury is neuropathic pain. By applying the above approaches including neuroimaging (fMRI), physiology (CHEP), and molecular biology, we also established an integrated system of neuropathic pain.
A parallel focus in this laboratory is to use the previously described technique to diagnose human neuropathies involving small-diameter nociceptive nerves (small-fiber neuropathy). This is quite a difficult issue for neurologists because there has been lack of objective methods to quantify the degeneration of small-fibers. We are among the pioneers in this field to diagnose small-fiber fiber neuropathies in patients with inflammatory neuropathies and diabetes mellitus.
We have extended our laboratory services to the diagnosis and therapy of human neuropathies: (1) CMT, including peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ), and connexin 32 and (2) FAP for the genetic mutations of transthyretin, the most common form of FAP.
1. Tseng MT, Tseng WY, Chao CC, Lin HE, Hsieh ST. Distinct and shared cerebral activations in processing innocuous versus noxious contact heat revealed by functional magnetic resonance imaging. Hum Brain Mapp 2010; in press.
3. Chao CC, Hsieh SC, Tseng MT, Chang YC, Hsieh ST. Patterns of contact heat evoked potential (CHEP) in neuropathy with skin denervation: correlation of CHEP amplitude with intraepidermal nerve fiber density. Clin Neurophysiol 2008; 119:653-661.
4. Chao CC, Sun HY, Chang YC, Hsieh ST. Painful neuropathy with skin denervation after prolonged use of linezolid. J Neurol Neurosurg Psychiatry 2008; 79:97-99.
YL, Chiang H,
8. Chao CC,
10. Chao CC, Hsieh ST, Shun CT, Hsieh SC. Skin denervation and cutaneous vasculitis in eosinophilia-associated neuropathy. Arch Neurol 2007; 64:959-965.
11. Chao CC, Hsieh SC, Yang WS, Lin YH,
12. Tseng MT, Hsieh
SC, Shun CT, Lee KL, Pan CL,
13. Lin CY, Su YN, Lee CN, Hung CC, Cheng WF, Lin WL, Chen CA, Hsieh ST. A rapid and reliable detection system for the analysis of PMP22 gene dosage by MP/DHPLC assay. J Hum Genet 2006; 51:227-235.
17. Lin YH, Hsieh SC, Chao CC, Chang YC, Hsieh ST. Influence of aging on thermal and vibratory thresholds of quantitative sensory testing. J Peripher Nerv Syst 2005; 10:269-281.
18. Chang YC,
20. Hsieh ST. Diagnosis and management of immune-mediated neuropathies. Acta Neurol Taiwan 2004; 13:39-45.
21. Hsu SH, Lee MJ, Hsieh SC, Scaravilli F, Hsieh ST. Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4) gene. Neurobiol Dis 2004; 16:335-345.
22. Pan CL, Shun CT, Susuki K, Yuki K, Hsieh ST. Pharyngeal-brachial palsy after cytomegalovirus colitis. Neurology 2004; 62:153-154.
23. Pan CL, Kuo MF, Hsieh ST. Auditory agnosia caused by a tectal germinoma. Neurology 2004; 63:2387-2389.
24. Shun CT, Chang
YC, Wu HP, Hsieh SC,
25. Pan CL,
27. Ko MH, Chen WP, Hsieh ST. Neuropathology of skin denervation in acrylamide-induced neuropathy. Neurobiol Dis 2002; 11:155-165.
28. Lyu RK, Chen WH, Hsieh ST. Plasma exchange versus double filtration plasmapheresis in the treatment of guillain-barre syndrome. Ther Apher 2002; 6:163-166.
29. Chien HF,
30. Lin YW,
31. Pan CL, Lin YH,
32. Pan CL, Yuki N,
33. Hsieh ST,
34. Chen WP, Chang YC, Hsieh ST. Trophic interactions between sensory nerves and the targets. J Biomed Sci 1999; 6:79-85.
35. Hsieh ST,
36. Huang IT,
37. Ko MH, Chen WP, Lin-Shiau SY, Hsieh ST. Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function. Exp Neurol 1999; 158:37-46.
Hsieh ST. Toxic neuropathies. In Schmidt RF and Willis
WD, editors. Encyclopedia of Pain.